Novel Conditioning Strategies Emerge in Gene Therapy, Leaving Busulfan—and Toxicities—Behind
September 12th 2025Speakers at an ASTCT Gene Therapy Summit highlighted novel conditioning approaches without the use of busulfan, which can cause toxic effects in patients with hematologic malignancies.
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FDA Expands Selumetinib to Children With NF1-Associated Plexiform Neurofibromas
September 10th 2025Selumetinib gains expanded FDA approval for younger pediatric patients with neurofibromatosis type 1 plexiform neurofibromas, enhancing treatment options and addressing significant disease-related challenges.
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PCV21 Shows Favorable Immunogenicity in Infants, Toddlers Receiving Pediatric Vaccines
September 10th 2025The 21-valent pneumococcal conjugate vaccine (PCV21) elicited favorable immunogenicity and safety in infants and toddlers who were coadministered common pediatric vaccines, such as the measles-mumps-rubella vaccine.
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Balancing Efficacy and Safety: Navigating Dose Adjustments and Therapy Optimization in Myelofibrosis
Jessica Lewis-Gonzalez, PharmD, BCOP, discusses the management of hematologic and non-hematologic toxicities in cancer patients, emphasizing the importance of proactive monitoring and collaboration between clinicians and pharmacists.
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Exploring the Antidepressant Potential of GLP-1 Receptor Agonists
GLP-1 receptor agonists show promise in alleviating depressive symptoms in patients with type 2 diabetes, offering a potential dual benefit in treatment.
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Aficamten Emerges as a Potential First-Line Therapy in Hypertrophic Cardiomyopathy
September 10th 2025Michael Fifer, MD, discusses the Maple HCM study, which compared the cardiac myosin inhibitor Aficamten and the beta blocker Metoprolol in patients with obstructive hypertrophic cardiomyopathy (HCM).
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Inside the Legislative Battle Over Oncology Patients’ Access to Critical Medications
Legislative efforts aim to improve oncology medication access, addressing transportation barriers and advocating for mail delivery from cancer clinics.
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