Psoriasis

Air pollution from the California Camp Fire are associated with increased rates of clinical; visits, according to new study results.

Deucravacitinib is an oral, selective, allosteric tyrosine kinase 2 inhibitor that inhibits cytokine signaling in psoriasis pathogenesis.

The findings provide an alternative delivery strategy for peptide-based drugs and suggest that such techniques and principles could be applied to a broader range of drugs.

The report highlights the growth of personalized medicines with improved efficacy for rare, previously untreatable diseases.

Results show an association between linoleic acid, found in nuts, seeds, and vegetable oils, and increased hypersensitivity in psoriatic lesions.

Clinical trials show that patients with atopic dermatitis experienced improved symptoms with dupilumab starting at 8 weeks, with maximum effect around 12 weeks.

All primary and ranked secondary endpoints of the study were met at week 16, which were sustained or improved through week 24 and were coupled with patient-reported improvements compared with placebo in treating psoriatic arthritis.

Adalimumab-aacf (Idacio) is indicated for chronic conditions such as rheumatoid arthritis, plaque psoriasis, ulcerative colitis, psoriatic arthritis, hidradenitis suppurativa, and juvenile idiopathic arthritis.

Study finds gluten-free diets may play an important role in the causality of celiac disease on the development of psoriasis.

A modified secukinumab dosing regimen produced outcomes on par with currently recommended intervals in patients with moderate-to-severe psoriasis, but longer follow-ups are needed to confirm the findings.

Psoriasis with coexistent lupus erythematosus is uncommon, shows a female preponderance, and is more likely to have joint involvement from both conditions.

Lipid pathways have been implicated in the pathogenesis of psoriasis and some lipid lowering drugs are believed to have disease-modifying properties.

Treatment with immune checkpoint inhibitors have the potential for immune-related adverse events, such as psoriasis.

Guselkumab (Tremfya) is a fully human selective IL-23 inhibitor therapy FDA-approved for the treatment of adults with active psoriatic arthritis and with moderate to severe plaque psoriasis.

The goals of therapy for atopic dermatitis include reducing symptoms of pruritis and dermatitis with disease control and prevention of flares.

These show promise as markers to help identify individuals with the conditions and develop targeted therapeutic options.

Four individuals in a new study achieve improvement, with a 35% to 70% reduction in PASI scores.

Psoriasis and end-stage renal disease are believed to share multiple pathogenic pathways, including various cytokines, reactive oxygen species, and psoriasis medications.

IMU-935 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan nuclear receptor gamma/truncated.

Research shows that patients with a severe form of psoriasis have a higher risk of death from cardiovascular disease.

The study confirmed that patients with psoriasis are considered to have an increased risk for both chronic kidney disease and ESRD, because inflammation plays a significant role in those conditions as well as heart disease.

Prior evidence regarding the safety and efficacy of the combination of apremilast and phototherapy was lacking, prompting researchers to investigate further.

Janssen’s GUIDE data demonstrate that patients treated with guselkumab less than 2 years after disease onset vs later are more likely to achieve “super-responder” at week 20 through 28.

Deucravacitinib is a selective, allosteric tyrosine kinase 2 (TYK2) inhibitor, which is a member of the Janus kinase (JAK) family.

It is currently indicated for the treatment of adult patients with active psoriatic arthritis and adult patients with oral ulcers associated with Behçet's Disease.

Boehringer Ingelheim’s monoclonal antibody inhibits interleukin-36 (IL-36) signaling and is the first treatment specifically approved for this indication.

Deucravacitinib (Sotyktu) may become the new standard of care oral therapy for moderate-to-severe plaque psoriasis, according to investigators.

Adalimumab-bwwd is a tumor necrosis factor blocker indicated for rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn disease, ulcerative colitis, and plaque psoriasis.

Tapinarof is a first-in-class topical steroid-free aryl hydrocarbon receptor antagonist intended to mitigate the symptoms of plaque psoriasis.

Indications for adalimumab include ankylosing spondylitis, Crohn disease, chronic plaque psoriasis, juvenile idiopathic arthritis, moderate to severe rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.