New Biomarker May Indicate Success of CAR T-cell Response in Lymphoma Patients
At leukapheresis, a low frequency of differentiated CD3+CD27-CD28--T cells can indicate favorable response to CAR T-cell therapy.
Experts Review Treatments, Directions in Basal Cell Carcinoma
Pharmacist involvement in identifying causes, therapy approaches is essential, as BCC can result from prior radiation therapy.
Phase 3 Trial Showed Zolbetuximab Significantly Improved Survival In Patients with Metastatic Gastric, Gastroesophageal Cancers
Zolbetuximab treatment reduced risk of death by 25% compared to placebo.
Investigational RSV Vaccine Demonstrates 83.7% Efficacy in Clinical Trial
Based on study findings, Moderna plans to submit for regulatory approval in the first half of 2023 for mRNA-1345, a novel vaccine for respiratory syncytial virus.
Pembrolizumab Plus Chemotherapy Significantly Improves Overall Survival in First-Line Advanced, Unresectable Biliary Tract Cancer
Specific data and results for pembrolizumab in patients with advanced or unresectable biliary tract cancer will be presented at an upcoming medical meeting and will be submitted to regulatory authorities.
Managing Patient Expectations May Improve Treatment of Anxiety, Depression
Study highlights the impact of individual expectations for positive and negative outcomes.
Mortality, Adverse Medication Events, Length of Hospital Stay Rises as More Organ Systems are Impacted by MIS-C Post-COVID-19
Multisystem inflammatory syndrome typically presents approximately 1 month after a COVID infection, occasionally resulting in cardiac complications in previously healthy children.
Probiotic Significantly Reduces S. aureus Colonization in Phase 2 Trial
The investigators observed a 96.8% S. aureus reduction in stool and a 65.4% reduction in the nose among patients who received the probiotic.
FDA Allows Access to Lifesaving Investigational Drugs
Compassionate use bridges gap between safety and patients' immediate need for biologics, devices, drugs, devices on spearhead of research and development.
Study Results Link COVID-19 to Higher Risk of Cardiovascular Disease, Death
Individuals with the virus had an 81 times higher risk of dying in the first 3 weeks of infection, and that remained 5 times higher for up to 18 months, analysis shows.
More Patients May Benefit from Pulmonary Embolism Surgery
Surgical embolectomy and venoarterial extracorporeal membrane oxygenation demonstrate favorable safety and efficacy profiles.
FDA to Review Application for Empagliflozin for Adults with Chronic Kidney Disease
In a phase 3 trial, empagliflozin significantly reduced the risk of kidney disease progression or cardiovascular death in adults with chronic kidney disease by 28% compared with placebo.
Data Analysis Finds Threshold for Lifting/Reinstating Masking to Combat Respiratory Illness
Research showed that 600 hospital beds filled with patients with severe illness would be enough to reimplement (mask mandates to stop the spread of infection.
Improving Management of Chronic Diseases in Rural Areas Begins with Maximizing Community Pharmacy Services
Community pharmacies are an untapped resource in rural areas but need to market their services to effect changes in public health.
Researchers Identify Molecular Mechanism Connected to Cancer, Heart Disease
New findings reveal the previously misunderstood mechanism by which PCSK9 degrades the low-density lipoprotein receptor.
COVID-19 Convalescent Plasma Transfusion Shows Decreased Mortality for Immunocompromised Patients With COVID-19
The therapeutic option is demonstrating favorable results for patients, despite the evolving nature of the SARS-CoV-2 virus.
Trial Results Demonstrate Significant Overall Survival With Zanidatamab in Adenocarcinoma
In patients with HER2-expressing metastatic gastroesophageal adenocarcinoma administered zanidatamab, the median duration of response was 20.4 months, with a median progression-free survival of 12.5 months.
An Overview of Pharmacist Involvement, Management in Treatment With Inclisiran
Luke Gormley, PharmD, BCPS, discusses how pharmacists are involved in the management of inclisiran.
Study Evaluates Impact of Pharmacy Liaison-Patient Navigators on ACO Hospital/ED Admission Rates
Enhanced care involves a pharmacy technician serving as a patient navigator who screens for health-related social needs quarterly and helps to connect patients with community resources.
Generic Product News for January 2023
Products include drugs for patients with stroke, bacterial infections, and acute pain.
2023 Forecasts for Pharmacy Services, Medication Costs During the Rise of Personalized Medicine
Data from a recent survey reflect a resounding shift toward the role of pharmacies becoming sites for primary care.
AHA: Stroke Symptoms, Even Those That Disappear Within 1 Hour, Need Emergency Attention
American Heart Association scientific statement recommends rapid evaluation for transient ischemic attacks.
Janssen, Global Partners Discontinue HIV Vaccine Study, Saying Regimen Is Not Effective
Independent, scheduled review of Phase 3 Mosaico clinical trial finds a lack of efficacy in preventing the infection.
Clostridium Difficile Infection Associated With Higher Mortality Rates in Intestinal Transplant Recipients
An organ transplant is a known risk factor for C. difficile infection, however, data are lacking on how the infection affects those who underwent an intestinal transplant.
Common Antidepressants May Impact the Ability To Learn From Our Environment
Patients on an SSRI were reportedly less likely to use positive or negative feedback to guide learning.
One Neural Network May Link Various Major Psychiatric Illnesses
The findings suggest that reduced gray matter is not the cause of psychiatric illness, although it is found in regions of the brain associated with it.
Amazon Pharmacy Introduces RxPass Generic Drug Subscription Service
The Amazon Pharmacy service will also have pharmacists on-call 24/7, according to the announcement.
COVID-19 Vaccine Can Prevent ICU Visit for Pregnant Women
Viral vector vaccines and a booster can protect maternal women against the Omicron variant of COVID-19, but the mRNA vaccine with a booster dose appears to offer the best protection.
Insulin Out-of-Pocket Cap of $35 Could Still Cause Economic Burden on Women, Racial, Ethnic Minorities
High cost-sharing is a large barrier to insulin access, as are aspects of the Inflation Reduction Act of 2022.
Atezolizumab, Bevacizumab is First Combination to Reduce Risk of Cancer Recurrence in Some Forms of Early-Stage Liver Cancer
Overall survival data were immature at the time of interim analysis and follow-up will continue to the next analysis.
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