CLINICAL ROLE -
FDA Issues Fast Track Designation to ADP101 for Mono-, Multi-Food Allergies
The designation allows expedited development of ADP101 as a treatment for food allergy in children ages 4 to 17 with confirmed allergy to 1 or more of the 15 foods in the drug product.
FDA Approves Tirzepatide for Chronic Weight Management
Tirzepatide is already approved under the brand name Mounjaro (Lilly) to be used along with diet and exercise to improve blood sugar in adults with type 2 diabetes.
FDA Approves Secukinumab for Hidradenitis Suppurativa
The approval marks the first new biologic treatment option for this patient population in nearly a decade.
Study Links Long COVID With Short Sleep Duration
Risk of long COVID was 3 times higher in those who had pre-existing conditions and a short sleep duration, compared to those with no pre-existing conditions and adequate sleep.
FDA Approves Zilucoplan for Generalized Myasthenia Gravis in AChR Antibody-Positive Adults
The approval marks the first and only once-daily target therapy for generalized myasthenia gravis for self-administration in this patient population.
Scholarship Program Aims to Improve Diversity, Equity in Pharmacy Field
If health care professionals want to increase access and care in these underrepresented communities, an important first step is also increasing the representation of those groups in health care itself.
FDA Approves Secukinumab as First Intravenous Interleukin-17A Antagonist for Rheumatic Diseases
The intravenous formulation of secukinumab is administered in monthly 30-minute, weight-based dosing and requires no pre-medication or lab monitoring.
Study Finds IVIG, Therapeutic Plasma Exchange Have Comparable Efficacy for Neurological Disorders
Choice of therapy should be selected based on patient needs and conditions.
Survey Highlights Need for Improved Working Conditions, Communication in Pharmacies
Although respondents reported no impacts on patient safety, workload significantly increased during the COVID-19 pandemic and led to major burnout challenges.
Axicabtagene Ciloleucel Demonstrates High Response Rate in Relapsed/Refractory Large B-cell Lymphoma
Axicabtagene ciloleucel achieved a complete metabolic response of 71% at 3 months versus 12% expected with standard of care among transplant ineligible patients with relapsed/refractory large B-cell lymphoma.
Phase 3 Trial Reinforces Favorability of Roflumilast Cream 0.05% for Atopic Dermatitis in Children
A supplemental New Drug Application will be submitted for roflumilast cream 0.05% for the treatment of mild to moderate atopic dermatitis in children 2 to 5 years of age.
Study: Shared Decision-Making in Cardiovascular Health is Infrequently Utilized, Despite Benefits
Shared decision-making can be better incorporated into cardiovascular care guidelines by including decision aids, such as informational flyers or online tools to help patients.
Experts Predict Multiple Myeloma Outcomes Will Improve With Greater Use of Bispecific Antibodies
Bispecific antibodies have 2 distinct binding domains, which interact with either CD3 on T cells or a tumor-associated antigen on the tumor cell surface.
Orforglipron Associated With Significant Weight Loss
As a once-daily oral treatment, orforglipron could help address barriers to injectable medications, such as semaglutide and liraglutide.
Study Suggests Base-Edited T Cells Could Minimize Immunotherapy Complications in Leukemia Treatment
The use of base editing to generate universal, off-the-shelf CAR T cells is a promising approach for relapsed leukemia, with potential implications for the future of gene therapy.
Bispecific Antibodies Achieve High Response Rates, Tolerable Adverse Effects in Multiple Myeloma
Bispecific antibodies have offered a new treatment approach in relapsed/refractory multiple myeloma, with promising results in preclinical studies for multiple cancers and hematological malignancies.
Study: Monitor Real-Time User Data to Optimize Digital HIV PrEP Programs
Telemedicine approaches for HIV can help reduce stigma that is often a challenge in face-to-face clinical settings and eliminate common logistical barriers, such as transportation.
Study Shows Not All IVIG Products Are Created Equal in Alzheimer Disease
One IVIG product showed overall improvement in neuroprotection, including alleviating cognitive decline and ameliorating AB deposition in Alzheimer disease.
Study Examines Links Between Sleep, Testosterone, and Cortisol in Aging Men
Hypercortisolemia during the late afternoon and early evening is harmful and believed to cause insulin resistance observed with advanced age.
Breaking Barriers and Inspiring Change: Female Pharmacy Owner Paves the Way for Success in Independent Practice
With pharmacies around the country shifting to provide more comprehensive care and becoming true health care destinations, Chichi Ilonzo Momah, PharmD, RPh said she is excited for the future of the field.
Point-of-Care Test Reagents Could Aid Risk Assessment for In-Home Care of Older Adults
In addition to improving risk evaluation in older adults at home, point-of-care testing may help clinicians manage patients with dementia who cannot communicate and those living in depopulated areas.
Research Identifies Defined Subtypes of Follicular Lymphoma, Marginal Zone Lymphoma
Correctly diagnosing specific follicular lymphomas and marginal zone lymphomas requires knowledge of the clinical context, including the site of involvement, age, and clinical presentation.
SGLT2 Inhibitors Not Associated With Improved Survival in Patients Hospitalized With COVID-19
In a previous trial, DARE-19, investigators reported that the SGLT2 inhibitor dapagliflozin did not benefit patients with COVID-19 who had cardiometabolic risk factors.
Study: More Than 1 in 6 Toddlers Do Not Complete Childhood Vaccine Series
Pharmacists can play a crucial role in educating parents and helping remind them about the childhood vaccine schedule, which can be quite complex.
Long-Term Follow-Up Data Show Consistent, Durable Response to Mavacamten in Patients With Obstructive Hypertrophic Cardiomyopathy
Results from the VALOR-HCM LTE trial at 56 weeks demonstrated that with longer follow-up, mavacamten continued to reduce patient eligibility for invasive septal reduction therapy.
Study: More Sleep Could Lessen Impulsive Behavior in Children
When children got less than the recommended 9 hours of sleep or took more than 30 minutes to fall asleep, there was a strong link to impulsive behaviors later in life.
Interpersonal, Community Factors Influence PrEP Engagement
Participants indicated that they would be more likely to accept PrEP-related information if it was recommended by a trusted person.
Study: Pain After Heart Attack Linked With Long-Term Survival
Notably, 65% of the participants experiencing pain at the 2-month follow up were also experiencing pain at their 12-month follow up, suggesting persistent and long-term pain.
Case Studies Show IVIG May Improve Neurological Symptoms in Pediatric Multisystem Inflammatory Syndrome
Relapses of MIS-C occurred in 2 patients due to rapid tapering of corticosteroids at 2 weeks instead of the standard protocol of 4 to 6 weeks.
Certain Brain Cells May Help Humans Stay Awake Longer Without Impacting Cognition, Health
Sleep loss is known to impact key processes such as attention, cognition, learning, memory, metabolism, and immune function.
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