C. difficile

Although investigative team is predominantly investigating Priscilicidin for topical applications, they are not ruling out potential oral applications.

New guidance provides recommendations on infection prevention strategies, performance measures, and how to implement these approaches.

Study findings mark the first evidence of improved health-related quality of life scores following treatment with an investigational microbiome agent in patients with recurrent Clostridioides difficile.

Study shows a statistically significant improvement in inflammatory syndrome after a fecal microbiota transplant in patients coinfected with COVID-19 and clostridioides difficile.

Investigators emphasize the importance of a timely HLH diagnosis and prompt initiation of treatment, as well as close outpatient follow-up to increase patient survival.

An organ transplant is a known risk factor for C. difficile infection, however, data are lacking on how the infection affects those who underwent an intestinal transplant.

Molecular methods such as polymerase chain reaction show promise in monitoring the patient environment in hospitals and could help to provide reassurance prior to admission.

Clostridium difficile is a gram-positive, spore-forming, bacterium that is mainly caused by recent hospitalizations, advanced age, or antibiotic treatments.

Patients with cystic fibrosis are typically administered antibiotics throughout their lives, which can increase the risk for C difficile infections.

Live-jslm (Rebyota; Ferring Pharmaceuticals) is indicated for the prevention of recurring Clostridioides difficile infection among patients 18 years of age and older after an antibiotic treatment.

The relative abundance of gram-negative Bacteroidetes to other phyla, such as gram-positive Firmicutes, is essential to maintain biodiversity and human gut health.

A gastroenterologist reviews the long-term impact of dysbiosis and Clostridioides difficile infection.

Dr. Tom Lodise provides an overview of gut microbiota and the consequences of dysbiosis.

Dr. Abraham discusses importance of differential diagnosis of C. difficile infection (CDI) in patients with IBD and how both IBD and CDI should be managed.

A gastroenterologist, Dr. Bincy Abraham, provides an overview of C. difficile infection (CDI) in patients with inflammatory bowel disease (IBD).

Drs. Lodise and Feuerstadt discuss educational opportunities to combat and reduce C. difficile infection (CDI).

Dr. Chopra shares multipronged approach to reducing C. difficile infection (CDI) and the role of antimicrobial stewardship.

Drs. Abraham, Chopra and Feuerstadt discuss importance of timely referral and diagnostic methods to discern C. difficile infection (CDI).

Drs Lodise and Feuerstadt discuss risk factors for C. difficile infection (CDI).

A gastroenterologist, Dr. Paul Feuerstadt, provides an overview of C. difficile infection (CDI) and vegetative and spore phases of CDI.

Immunoinformatics allows researchers to develop vaccines without microbial culturing, thus saving time and money.

Analysis shows that the common infection may be a driver of the disease in adults younger than aged 50 years.

This inflammation of the colon poses a substantial burden to patients and the health care system.

Pharmacy Times spoke with Paul Feuerstadt, MD, FACG, AGAF, about the investigative C. difficile treatment RBX2660.

The first step to reducing recurrent C. difficile infections is prevention.

Paul Feuerstadt, MD, FACG, AGAF, discussed the investigative C. difficile treatment RBX2660 and how it impacts time to recurrence.

Paul Feuerstadt, MD, FACG, AGAF, discussed research into the novel C. difficile treatment RBX2660 and what investigators have found about its efficacy in key subgroup analyses.

Ken Blount, PhD, chief scientific officer at Rebiotix, discusses the investigative treatment RBX2660 and its unique approach to treating Clostridioides difficile infection.

In ECOSPOR III, the lead therapeutic candidate incorporated itself durably and rapidly into the microbiome to prevent recurrence, the company says.

The organizations emphasized the need to better understanding the patient experience for those with recurrent CDI.