CLINICAL ROLE -
Maintaining Cross-Specialty Communication Can Help Mitigate the Impact of Cancer Drug Shortages
A panel hosted by HOPA, ACCC, and AVAHO discusses strategies to ensure patient access to treatment.
The Growth of Biosimilars Continues to Create Hope for Lower Drug Costs
Perhaps the most significant development in the pharmaceutical industry in decades, crops of biosimilars are being approved and are ready for distribution. What lies next, in terms of legislation and the impact on pharmacists, remains to be seen.
Study Data Shows Potential of Gene Signatures to Predict Treatment Response in Patients With Recurrent Prostate Cancer
The research was aided by the Decipher Genomics Resource for Intelligent Discovery, which helped derive the gene signatures used during the analysis.
FDA Clears Investigational New Drug Application to Treat Amyotrophic Lateral Sclerosis
The drug can now be tested for safety, tolerability, and efficacy in a phase 1 study.
FDA Approves Remdesivir to Treat COVID-19 in Patients with Hepatic Impairment
The drug is the first approved antiviral COVID-19 treatment that could be used across all stages of liver disease.
Novel Mechanism of Action of FloraStilbene Suggests Potential for Enhancing Efficacy of Checkpoint Inhibitor, CAR-T Therapies
Protection of T cells from tumor-induced suppression suggests potential for enhancing efficacy of therapies, with plans to initiate a phase 1/2 clinical trial in patients with advanced breast cancer.
FDA Accepts New Drug Application for Imetelstat for Treatment of Lower Risk Myelodysplastic Syndromes
The drug showed statistically significant and clinically meaningful efficacy results across key subgroups.
FDA Approves Vaccine for Pregnant Individuals to Prevent Respiratory Syncytial Virus in Infants
It is the first vaccine of its kind to be FDA approved, and it met multiple safety and efficacy standards through clinical trials.
Esketamine May Boost Efficacy of Oral Antidepressants in Patients with Fluctuating Response
Researchers sought to find a remedy for the development of treatment-resistant depression in patients whose antidepressant treatment has fluctuated in efficacy.
FDA Approves Treatment for CD55-Deficient Protein-Losing Enteropathy
The treatment is the first of its kind to be FDA-approved to treat CHAPLE disease.
New Model Can Effectively Predict Intravenous Immunoglobulin Resistance in Patients With Kawasaki Disease
The model was the first to incorporate C-reactive protein/albumin ratio and apply LASSO regression analysis to a predictive model for children with Kawasaki disease.
Child Tax Credit Payments Corresponded With Increase in Odds of Low Birth Weight
The results differ from previous studies and the predictions of the researchers that the Child Tax Credit would reduce the prevalence of low birth weight among pregnant women across the country.
Case Study: Positive HIV-1 Status Should Not Preclude Heart Transplant
Previous studies have shown promising results with liver or kidney transplants in patients with HIV, but there was a lack of literature regarding heart transplants specifically.
Use of First-Line Treatment for Insomnia Low Among Adults With Mental Health Conditions
Although the rate of people with probable insomnia who discussed their sleep habits with a physician was relatively high, the number of people who went on to seek actual treatment was low.
Biosimilar Aflibercept Shows Positive Efficacy and Safety Results in Confirmatory Study
The Mylight phase 3 trial confirmed that there was no clinically meaningful differences between aflibercept and its reference biologic, Eylea, for patients with wet macular degeneration.
Tucatinib Plus Ado-Trastuzumab Meets Progression-Free Survival Endpoint in Patients With HER2-Positive Breast Cancer
The combination regimen showed positive progression-free survival results among patients with HER2-positive breast cancer in the phase 3 HER2CLIMB-02 trial, but overall survival data have yet to mature.
New Telepharmacy Openings Associated With Reduction of Pharmacy Deserts
Researchers recommended less restrictive policy regarding telepharmacies to improve access to medications and pharmacists, while ultimately improving outcomes and adherence to treatment regimens.
HIV Experts Discuss Conditions, Functionalities for Patient Use of COMTRAC-HIV App
Topics discussed include care workflow, app functionalities, problems and disadvantages, and benefits for HIV experts.
Alcohol Consumption, Risky Drinking Habits Common Among Cancer Survivors, Those Receiving Treatment
Unexpectedly, a study found that more than 70% of cancer survivors were current drinkers, indicating the need for intervention and strategies to reduce harmful drinking habits.
Case Study: Intravenous Immunoglobulin Can Treat Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis in Pediatric Population
Intravenous immunoglobulin was found to be the most effective immunotherapy in preventing relapses after treatment with steroids in pediatric patients.
Potential Associations Found Between Microbiome, Early Cognitive Development in Infants
Key study finding shows associations between the beat frequency in the rhythmic stimulus in the frontal left sites of infant brains and pathways related to brain modulation and nucleotide levels.
Common Cold Virus Associated With Rare Blood Clotting Disorder
Prior to this study, anti-platelet factor 4 disorder was thought to be caused by exposure to heparin or autoimmune conditions.
Perioperative Gabapentinoids May Alleviate Pain, Reduce Opioid Use in Patients Undergoing Spine Surgery
A dose of 900 mg per day of gabapentin prior to spine surgery was associated with the lowest pain score among all studied dosages.
Case Study: Respiratory Syncytial Virus May Cause Complications in Pregnant Patients
Although not a traditional at-risk group for severe respiratory syncytial virus complications, pregnant patients should be aware of the possibility of infection and be educated on proper prevention procedures.
Experts Create Guidelines for Management of Acetaminophen Poisoning
A panel released recommendations in accordance with decades of a changing landscape in acetaminophen poisoning and due to an absence of agreed upon guidelines in the space.
No Association Found Between COVID-19 Pandemic and Incidence of Health Care-Associated C. Difficile Infections
Prior studies had produced conflicting results on whether the pandemic positively or negatively impacted health care-associated C. difficile infections, yet the results of this current study indicate the pandemic played a limited role.
Significant Increase in Hospital Delirium, New Antipsychotic and Benzodiazepine Prescriptions Associated With COVID-19 Pandemic
Unexpectedly, the highest increases in delirium compared to projections were in the 66 to 74 years of age group, which could have important personal and societal repercussions, such as earlier development of dementia.
Low Probability of 5% Weight Loss in Adults With Overweight or Obesity
Despite the low uptake of healthy lifestyle behaviors to achieve 5% weight loss or greater, the probability of weight loss increased among individuals with higher initial BMI.
Expert Discusses Current Recommendations for Respiratory Syncytial Virus, Influenza, COVID-19 Vaccination
Gretchen Garofoli, PharmD, an associate professor at the West Virginia School of Pharmacy, discusses the current recommendations for COVID-19, respiratory syncytial virus (RSV), and influenza vaccines and vaccine hesitancy.
Remibrutinib Shows Rapid Symptom Control in Chronic Spontaneous Urticaria
Results of phase 3 trials could lead to the approval of remibrutinib to provide more effective and controlled treatment of chronic spontaneous urticaria than H1-antihistamines.
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