CLINICAL ROLE -
Phase 2 Trial Data Show That Novel Antibiotic Led to 96% Cure Rate for C diff Infection
Iberzaplstat was non-inferior to standard of care vancomycin, was safe and tolerable, and will advance into a phase 3 trial.
Potential Host, Viral Mediators of NSV Identified, May Represent Targets to Disrupt HIV Persistence
Further research of these mechanisms could be significant in developing future strategies to disrupt the viral persistence in individuals living with HIV.
Gene Associated With Autism Spectrum Disorder May Disrupt Early Brain Development
Patients with this genetic variant have impaired neuronal excitability, a trait that has been linked to malfunctional synapses.
Study Finds Asthma-Related Mortality Rates High in US, Factors Include High BMI, Smoking
The study also showcases a significant decline in asthma mortality rates in China, which were previously higher than the United States from 1990 to 2019.
FDA Offers Priority Review to Enfortumab Vedotin-Ejfv, Pembrolizumab Combination for Metastatic Bladder Cancer
If approved, this combination will become a first-line treatment option for patients who are cisplatin eligible.
Biosimilar Candidate GP40141 Found Similar to Romiplostim for Idiopathic Thrombocytopenic Purpura
The aim of developing GP40141 as a biosimilar is to help reduce the cost of the drug and make treatment more affordable for those with idiopathic thrombocytopenic purpura, according to investigators.
Removing Medicaid Prior Authorizations for Buprenorphine May Not Increase Prescribing
Non-expansion states had an increase in prescriptions after PA removal at 27.3% and Medicaid expansion states demonstrated a 22% decrease in prescriptions.
Equity-Centered Approaches Can Help Improve Care for MSM Living with HIV
According to the authors, current HIV care methods demonstrate that the mean age at death for Black MSM was 68.8 years, whereas the mean age for White MSM was 75.6 years.
Acoustic Stimulation May Significantly Impact Adults Who Have Persistent Symptoms Following Concussion
Following acoustic stimulation intervention, many patients experienced a reduction in neurobehavioral symptoms.
Study: Cholesterol in Brain Associated Alzheimer Disease, Brain Damage
Investigators believe lowering cholesteryl ester levels could help prevent brain damage and behavioral changes, reducing the risk of Alzheimer disease.
Study: Income Associated With Cardiologist Care for Those With Heart Failure
Although involvement of a cardiologist for heart failure has been associated with reduced rates of in-hospital mortality, not all patients see a cardiologist when hospitalized, according to the investigators.
Addressing Burnout: Employees Are Lonelier Than Ever
Many workers don’t advertise their level of loneliness, nor do they know the impact of loneliness on their well-being.
Enhancing Patient-Centric Oncology Care: The Crucial Role of Oncology Pharmacists in Treatment Decision-Making
Marlo Blazer, PharmD, BCOP, discusses the collaborative nature of the pharmacist's role within the oncology care team.
Early-Life Stress Combined With Traumatic Brain Injury Could Increase the Brain’s Vulnerability to Negative Programming
An animal study shows that early-life stress may increase risk-taking behaviors in adulthood; in humans, this could translate to risk of substance use disorder.
Data From Phase 3 Trials Demonstrate Efficacy of Dupilumab for Treating COPD, Type 2 Inflammation
Patients with uncontrolled chronic obstructive pulmonary disease and type 2 inflammation had significantly better lung function at least a year into dupilumab regimen.
Supplement Derived From Mollusks Could Reduce Age-Related Osteoporosis
Nacre may combat cortical bone loss and improve bone strength to reduce risk of fragility fractures.
Study Finds Potential New Target, Drug Candidate to Treat Patients with Barth Syndrome
These findings could make a significant difference in treating patients with Barth syndrome, which is an incurable genetic disease.
One Night of Sleep Deprivation May Significantly Impact Decision Making
Neuroimaging showed that people who lacked sleep had altered risk-taking behaviors.
Clinical Updates: Treatment Options for COVID-19
With wider testing available, diagnosing COVID-19 has become easier and many patients now have access to important treatment options.
Survey Results Find High Rate of Inadequate Health Care Coverage Among US Children
There is a great need to protect families and children that are commercially insured following the COVID-19 pandemic.
Study: Age Negatively Associated with Contralateral Breast Cancer Development After Primary Treatment
Further research is necessary to better understand the development and factors that contribute to CBC after PBC treatment.
FDA Issues Warning Of Antiseizure Medications Causing Rare, Serious Reactions
Drug reaction with eosinophilia and systemic symptoms can start as a rash and quickly progress, affecting the internal organs and requiring hospitalization, even resulting in death.
Survey Results Show Significant Number of Children Are Using Melatonin for Sleep
Melatonin is not fully regulated by the FDA, and there are concerns about children taking the supplement due to associated risks, such as dependency and overdose.
Grant Aims to Strengthen Vaccine Production in Africa
By strengthening the continent's health care infrastructure, promoting local vaccine production, and facilitating global collaborations, the grant represents an important milestone toward better health care for all Africans.
Treatment for Traumatic Brain Injury May Be Informed By Glucose Variation
Patients hospitalized for traumatic brain injury have different brain injury biomarkers and rates of glucose variation.
FDA Grants Orphan Drug Designation to KRP203 Following allo-HSCT in Patients with Hematologic Malignancies
This is KRP203’s second Orphan Drug Designation and it is the only S1P receptor modulator being developed as an adjunctive and maintenance treatment for blood cancers.
Home Monitoring of Asthma Symptoms Found Effective with Use of AI-Aided Stethoscope
This innovation could be useful for optimizing the collaboration between patients with asthma and their health care providers through remote telemedicine consultations.
Melanoma LIMS, Algorithmic-Based Classification Achieves Specificity, Precision in Skin Cancer Diagnosis
The study authors are encouraged by the findings, noting that LIMS with algorithmic-based classification can aid in early and accurate diagnosis of skin cancer, improving patient prognosis.
HLA-DQA1*05 Genotype Does Not Influence Clinical Response to Ustekinumab, Vedolizumab
No significant demographic or phenotypic differences were found between HLA-DQA1*05 carriers versus non-carriers, in either treatment group.
Novel Artificial Intelligence Tool Predicts Outcomes in Invasive Breast Cancer
In addition to predicting breast cancer outcomes, the AI tool can help determine effective treatment options in patients, sparing them from unnecessary treatments.
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