CLINICAL ROLE -
Study: Patients With PD-L1-Positive, High-Risk, ER+/HER2- Breast Cancer Can Achieve Substantial Complete Response Rates With Addition of Nivolumab
Patients with an estrogen receptor measure greater than 8% and those with little to no TIL expression showed no benefit with the addition of nivolumab.
Expert Discusses A Health System Specialty Pharmacy Initiative: Abemaciclib Linkage to Care
Carly Giavatto, PharmD, discusses the CPS conducted study that highlights a first of its kind linkage to care initiative performed by health systems specialty pharmacists.
It’s High Time We Consider Differential Reimbursement
All fills are not equal in their complexity and cost.
MONALEESA Pooled Analyses Show Quality of Life Is Maintained in Elderly Patients Receiving Ribociclib, Endocrine Therapy
The investigational combination also delayed the median time to first chemotherapy in all age groups.
HIV/AIDS Awareness Month Highlights Opportunities for Pharmacy
As HIV has become a manageable chronic condition, and even curable in some cases, the role of pharmacists cannot be understated.
New Capivasertib Approval Benefits Patients With Breast Cancer, PIK3CA/AKT1/PTEN Alterations
Biologic rationale, biomarker precision, and efficacy results in the biomarker-negative population all helped FDA officials decide the final indication.
FDA Approves Iptacopan for the Treatment of Paroxysmal Nocturnal Hemoglobinuria in Adult Patients
During clinical trials, individuals treated with iptacopan had increased hemoglobin levels and did not need to receive blood transfusions.
Experts Say More Research Is Needed to Understand Obesity-Cancer Link
Evidence has shown that reversing pro-cancer effects requires significant weight loss as well as substantial metabolic reprogramming.
Patients With Breast Cancer Who Skipped RNI Did Not Experience Increased Risk of Disease Recurrence
Patients with breast cancer who underwent chemotherapy and skipped RNI did not face an increased risk of disease recurrence or death 5 years post-surgery.
Study Results Indicate Combined Therapy of Tucatinib, T-DM1, Extended PFS in Patients With Breast Cancer
Although PFS was improved in patients with unresectable locally advanced or metastatic HER2-positive breast cancer, OS data were immature, requiring further research.
Expert Discusses Circulating Tumor DNA Monitoring for Early-Stage Breast Cancer
Mridula George discusses the role of personalized circulating tumor DNA monitoring in predicting the response to neoadjuvant therapy for early-stage breast cancer.
Study: Older Patients With Actinic Keratoses at Increased Risk of Skin Cancer
Patients enrolled in the study had substantial absolute risks and elevated relative risks, suggesting that AKs may be a clinical marker of UV exposure and increased skin cancer risk.
FDA Experts Review Data, Regulatory Insights for New Metastatic Breast Cancer Treatments
Trastuzumab deruxtecan and elacestrant both represent important new treatment options for subgroups of patients with breast cancer.
Study Finds Inavolisib Combination Treatment Improved PFS in Patients With Breast Cancer
In the first-line setting, inavolisib plus palbociclib and fulvestrant improved PFS in patients with HR-positive breast cancers; however, further research is needed to understand the trends in OS.
FDA Approves 2 Label Changes to Levothyroxine Sodium for the Treatment of Hypothyroidism
The approval marks levothyroxine sodium as the only FDA-granted LT4 therapy that does not have a labeled interaction with PPIs and can be taken 15 minutes prior to eating breakfast.
People With Epilepsy May Have Mechanisms Within Their Brain to Reduce Epileptic Activity
These patients have slow brain wave activity during wakefulness, which can reduce the firing of nerve cells to protect against the pathology of epilepsy.
Long-term Chia Seed Supplementation May Significantly Lower Systolic Blood Pressure
Chia seeds are a nutrient dense product that are rich in fiber and omega-3 fatty acids, and could have a hypocholesterolemic effect when ingested.
Removing Barriers That Limit Young Men at Risk for HIV Will Improve Access to PrEP
The study authors note that increasing education, implementing online services, and removing stigma can help improve the uptake of PrEP in this population.
Reducing The Cost of Care for Health Systems: Ensuring Access to Critical Medications for Patients
Peter J. Siavelis, discusses the role of the InteLogix platform to enable a more rapid response to changes in the pharmaceutical supply chain.
FDA Grants Orphan Drug Designation to LP-284 for Treatment of HGBL With MYC, BCL2 Rearrangements
Currently, there is no established standard of care treatment approach of HGBL, with frontline interventions consisting of chemo-immunotherapies.
New Risk Factor Found for Future Cardiovascular Disease in Patients With Systemic Lupus Erythematosus
Investigators found that positive antiphospholipid antibodies and traditional risk factors were associated with atherosclerotic cardiovascular disease.
Top 5 Sessions, Interviews From the 2023 San Antonio Breast Cancer Symposium
Pharmacy Times will be covering the 2023 San Antonio Breast Cancer Symposium (SABCS), happening December 5 through 9 in Texas.
Expert: Semaglutide Versus Tirzepatide, How Both Can Aid Type 2 Diabetes and Obesity
Jennifer N. Clements PharmD, BCACP, BC-ADM, BCPS, CDCES, FADCES, FCCP discusses the role of Semaglutide and Tirzepatide for type 2 diabetes and obesity
Novel Technology Could Reduce Weight Control Drug Injections for Patients With Diabetes
A new hydrogel drug delivery system could change the way diabetes is managed.
Reduced Structural Stigma Against Sexual Minorities Is Associated With Greater Rates of Male PrEP Prescriptions
The study authors note that additional policies to reduce structural stigma against sexual minorities could continue to improve the rate of individuals who initiate PrEP use.
FDA Approves Pirtobrutinib For Treatment of Adult Patients With CLL, SLL
Pirtobrutinib is the first and only non-covalent BTK inhibitor to be approved by the FDA and is indicated for adult patients who already received at least 2 prior lines of therapy.
Study: Substantial Deficiencies in Capture of Cognitive Safety in Drug Trials
Despite nearly one-third of reversible dementia cases being drug induced, cognitive safety is a neglected aspect of clinical trials.
Migraine Medication Could Be More Effective Than Ibuprofen for Treatment of Attacks
Three classes of drugs could be 2 to 5 times more effective than ibuprofen for the treatment of migraine attacks, according to results of a study.
Survey Finds Individuals Worried About Infection During Upcoming "Tripledemic"
Fewer individuals have received the flu shot this season, compared to previous years.
Certain Personality Traits May Lower the Risk of Developing Dementia
Although personality was linked to cognitive performance on tests, it was not linked to dementia pathophysiology.
2 Clarke Drive Cranbury, NJ 08512