Five-Year Results From the NATALEE Trial: Evaluating Ribociclib in Early Breast Cancer
By Rose DiMarco, PharmD, BCPS, BCOP,Heather Moore, BCOP, CPP, PharmD,Julia Ziegengeist, PharmD, BCOP,Jordan Hill, PharmD, BCOP The panelists examined the 5-year follow-up data from the NATALEE trial, which evaluated the addition of ribociclib to a nonsteroidal aromatase inhibitor in patients with early breast cancer. Faculty examined how the patient population, study design, and clinical endpoints in this trial differed from those used in the monarchE trial. The discussion highlighted important distinctions in eligibility criteria and outcome measures that may influence interpretation of results. Experts reviewed the key efficacy findings from the 5-year analysis and discuss the safety profile observed with ribociclib in the adjuvant setting. Particular attention was given to how these outcomes inform the role of CDK4/6 inhibition in early-stage disease. Faculty shared their perspectives on the most meaningful clinical takeaways from the updated data. Finally, the panel compared the findings from NATALEE with the long-term results from monarchE and discuss how these studies together may shape treatment strategies and decision-making in clinical practice.