Oncology

This indication has received accelerated approval based on tumor response rate and durability of response, though the results of confirmatory trials may change the approval status.

IQVIA researchers saw a sharp uptick in medication usage shortly before the COVID-19 pandemic began, followed by a steep fall in the first few months of the pandemic.

Although young women were the original targets of human papillomavirus vaccine outreach after its approval in 2006, the increasing rates oropharyngeal cancer has made vaccination for young men even more important.

The study also found that patients with comorbidities such as heart disease and diabetes were more likely to experience a high symptom burden.

An interim analysis from the phase 3 ALPINE trial comparing zanubrutinib against ibrutinib demonstrated positive results in the treatment of relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.

Kenneth Komorny, PharmD, BCPS, a co-lead on development of National Comprehensive Cancer Network recommendations for biosimilar management, explains some of the positions the NCCN has taken.

Health care practitioners and manufacturers must change practice patterns and management strategies.

Individuals with an average risk of colorectal cancer said they would prefer a stool-based screening test for colorectal cancer over colonoscopy.

The relatively new combination of PD-1/PD-L1 inhibitors with VEGF inhibitors represents a promising option for patients with various malignancies.

Pharmacists must work to keep patients informed and safe so they can continue to deliver lifesaving cancer care.

Directions in Oncology Pharmacy® is getting to know oncology pharmacy professionals through a series of interviews. In this issue, we talk to David DeRemer, PharmD, BCOP, FCCP, FHOPA, president of the Hematology/Oncology Pharmacy Association (HOPA) Board of Directors, whose term ends this month.

As the most accessible member of the health care team, the pharmacist can provide patients with cancer with the information and support necessary to get through what could be the most challenging time in their lives.

Clinicians should consider the impact on subsequent therapies, overall survival, and median time to definitive deterioration with CDK 4/6 inhibitors.

Cynthia Lynch, MD, breast cancer program clinical advisor with Cancer Treatment Centers of America, said oncology pharmacists are vital team members who can help ensure optimal treatment and safety for patients with breast cancer.

Investigators developed a genetically distinct and non-toxic strain of salmonella called CRC2631 to select and kill cancer cells, which may be able to be tailored to specific patients.

Oncology experts recommend patients schedule overdue screenings, as pandemic restrictions ease.

Loncastuximab tesirine-lpyl is a CD19-targeted antibody drug conjugate.

According to the study authors, the findings suggest a need for greater transparency in health care pricing as well as policies eliminating financial obstacles to catching cancer early.

Novel therapeutics under investigation include CAR T-cell therapies, antibody-drug conjugates, and bispecific antibodies, as well as other unique drugs.

New research findings published in Cell Reports identified a type of immune cells that acts as a major driver of breast cancer growth by preventing the accumulation of a specific protein that induces anti-tumor responses.

The study further explored the various aspects of financial hardships, including material, psychological, and behavioral measures.

Immunotherapies will continue to change standards of care for treatment of RCC.

One mutated version of KRAS that commonly arises in cancer cells is called KRAS(G12C) and it produces a mutated KRAS protein that allows the cells to grow and spread in the body.

The study shows that brentuximab vedotin allowed for reduced radiation exposures and resulted in fewer adverse effects for patients, according to its authors.

A new study led by researchers at NYU Rory Meyers College of Nursing found that breast cancer survivors with a higher risk of cancer recurrence based on genomic testing may experience greater fear of their cancer returning.

A new study shows that overweight breast cancer survivors have a statistically significant increased risk of developing second primary cancers, and obesity is strongly associated with an increased risk of various cancer types.

Nivolumab is the first and only immunotherapy in combination with chemotherapy to deliver superior overall survival compared to chemotherapy alone in this patient population.

Among somatic mutations, approximately 89% of patients with metastatic castration-resistant prostate cancer have a potentially actionable mutation.