The Pharmacy Times® Pharmacy Hospital Clinical Role section is a comprehensive resource for clinical news and expert insights on issues pertaining to hospital and health-system pharmacists.
June 7th 2023
It’s time for pharmacies to take a page out of the books of hospitals and tech companies by expanding and streamlining their use of contingent labor.
FDA Grants Fast Track Designation to Milvexian for Multiple Prospective Cardiovascular IndicationsJune 6th 2023
The proposed indications for milvexian include stroke prevention after an acute ischemic stroke or high-risk transient ischemic attack; recent acute coronary syndrome; and atrial fibrillation.
Dual Bispecific Combination Study Shows 96% Overall Response Rate in Relapsed/Refractory Multiple MyelomaJune 6th 2023
Findings highlight the potential efficacy of combining 2 novel bispecific therapies, teclistamab-cqyv and talquetamab, which target distinct antigens on myeloma cells.
Long-term Data Show Efficacy of Amivantamab-vmjw Combination for Patients With Mutated Advanced Non-Small Cell Lung CancerJune 5th 2023
In data presented at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting, amivantamab-vmjw plus lazertinib demonstrated promise as a first-line treatment for patients with advanced EGFR-mutated non-small cell lung cancer.
Overall Survival of Patients With Metastatic NSCLC Sustained Up to 4 Years With Opdivo, Yervoy CombinationJune 5th 2023
Nivolumab plus ipilimumab combination improved overall survival, with 21% of individuals with metastatic non–small cell lung cancer treated with the combination and 2 cycles of chemotherapy alive compared to 16% with chemotherapy alone.
Durvalumab, Olaparib Combination Improves Progression-Free Survival in Patients With Advanced Ovarian CancerJune 5th 2023
Positive findings in patients with advanced high-grade epithelial ovarian cancer were presented during an oral presentation at the 2023 American Society of Clinical Oncology Annual Meeting.
FDA Approves First Intravenous Iron Replacement Therapy for Adults With Heart Failure, Iron DeficiencyJune 5th 2023
Treatment with Injectafer significantly improved exercise capacity compared to placebo in a randomized clinical trial in adult patients with heart failure.
Clinical Overview: Steps to Implementation of Rebyota for Recurrent C difficile InfectionJune 5th 2023
Rebyota is a live biotherapeutic product that is unfamiliar to many pharmacists and other health care providers with different steps in the eventual administration process.
Overall Survival Results Reinforce Osimertinib is Now Standard of Care for EGFRm Stage IB–IIIA NSCLCJune 5th 2023
Updated overall survival and safety profile data from the global phase 3 ADAURA trial provide practice-changing findings with adjuvant osimertinib (Tagrisso; AstraZeneca) in patients with resected EGFR-mutated stage IB–IIIA NSCLC.
Analysis of Gut Microbiome Did Not Show Significant Differences Relating to Immune Checkpoint Inhibition ResistanceJune 3rd 2023
Fecal microbiota transplant from responders to non-responders was able to rescue immune checkpoint inhibition use in patients with melanoma, with 40% of patients showing clinical benefit.
Larotrectinib Subgroup Analyses Demonstrate Long-Term Efficacy, Safety Profile in NTRK Gene Fusion CancerJune 2nd 2023
Findings presented at the American Society of Clinical Oncology (ASCO) 2023 meeting show the long-term efficacy and safety profile of larotrectinib (Vitrakvi; Bayer) in solid tumors with NTRK gene fusion.
Clinical Overview: Dapagliflozin for Patients with Heart Failure, Reduced Ejection Fraction and Preserved Ejection FractionJune 2nd 2023
Management of heart failure focuses on avoiding reversible precipitants and optimizing guideline-directed therapy to lower mortality and hospitalizations.
Ribociclib Lowers Risk of Disease Recurrence by 25% for Early Breast CancerJune 2nd 2023
Ribociclib (Kisqali) demonstrated a 26% risk reduction in distant disease-free survival and a 28% risk reduction in recurrence-free survival in patients with HR+/HER2- early breast cancer.
COVID-19 Infection Could Be Detected in Lungs, Heart, Causing Inflammatory DamageJune 2nd 2023
Investigators found thinner ventricular walls, disorganized and ruptured myocardial fiber, mild inflammatory infiltration, and mild epicardia or interstitial fibrosis in the hearts of mice infected with COVID-19.
FDA Approves Olaparib Plus Abiraterone, Prednisone for Metastatic Castration-Resistant Prostate CancerJune 1st 2023
Investigators previously reported a statistically significant improvement in radiographic progression-free survival in the full intention-to-treat population of adults with deleterious or suspected deleterious BRCA-mutated metastatic castration-resistant prostate cancer.