CLINICAL ROLE -
Study Shows Association Between Alpelisib Treatment, Hyperglycemia in Patients with Metastatic Breast Cancer
The study authors suggest that after initiating alpelisib, patients should be proactive by improving glycemic status to reduce the risk of developing hyperglycemia.
Analysis Indicates Sleep Duration, Health Influenced by Environmental Changes
Environmental factors may change sleep patterns over time, which subsequently affects rapid eye movement sleep.
Trial Results Find Enfortumab Vedotin-ejfv, Pembrolizumab Combination Effective in Urothelial Cancer
The combined enfortumab vedotin-ejfv and pembrolizumab treatment is recommended for patients with locally advanced or metastatic urothelial cancer who are ineligible for cisplatin-containing therapy.
Intervention with Supplemental Creatine Found Effective, Safe for Symptom Reduction After COVID-19 Infection
At a 6-month follow-up, supplemental creatine intervention significantly improved scores for fatigue symptoms and tissue bioenergetics related to COVID-19 infection.
Study Results Indicate Purpose in Life Declines with Emergence of Cognitive Impairment
Maintaining a purpose in life has the potential to reduce apathy related to dementia and cognitive decline.
House Committee Hearing Addresses PBMs, Anticompetitive Drug Pricing Tactics
The House Committee members examined pricing tactics by PBMs and how they are harming patients across the country.
IVIG Therapy Shows Insignificant Benefit to Reducing Mortality, Length of Hospitalization in Patients with COVID-19
The analysis results showed no statistically significant impact on either outcome, but results from prior prospective studies suggest that intravenous immunoglobulin may lengthen hospital stay for patients with severe COVID-19.
Study Demonstrates Insufficient Sleep, Circadian Misalignment Associated with Obesity
In addition to identifying strategies to reduce the adverse effects of sleep and circadian disruption, the study authors identify the impact of obesity on sleep.
Analysis Indicates Highly Cited COVID-19 Research is Trending Downwards Compared to Early in Pandemic
Research shows a peak of highly cited COVID-19 studies at the end of 2021 and a significant downward trend by the end of 2022.
Expert: Artificial Intelligence Changing the Field of Medical Writing
The CEO of Yseop discusses how AI can have a positive impact in the development of high quality medical writing due to its efficiency and ability to reduce long, tedious tasks for writers.
SARS-CoV-2, Seasonal Influenza Vaccine Coadministration is Safe, Effective in Protection Against Viruses
Compared with COVID-19 vaccination alone, recent study findings show health care workers who received both a COVID-19 booster and influenza vaccinations did not have lower immune response or more frequent adverse events.
Patients With Cancer Using Nonmedical Stimulants Can Continue Using Opioids, Regardless of Prognosis
Experts agreed that it was appropriate for patients who use methamphetamine or cocaine to continue opioid use if clinician monitoring was increased and tapering was avoided.
Neuraminidase Inhibitor, Polymerase Inhibitor Use for Influenza Treatment Continues, Other Methods Considered
While monitoring influenza virus resistance as it develops, researchers are prioritizing further investigations to decrease the risk of resistant strains.
Neuraminidase Inhibitors, Endonuclease Inhibitors Significant for Influenza Pandemics, Foundational for Further Antiviral Support
Having 2 drug classes available for influenza is significant, but it is important to investigate other treatments prior to the pandemic, a new study indicates.
Phase 3 Trial Shows Combined Nivolumab, Ipilimumab Treatment Improved OS in Patients With mNSCLC
Compared to chemotherapy alone, the combined nivolumab and ipilimumab treatment more than tripled the overall survival rate at 6 years in patients with PD-L1 expression <1%.
California Bill to Decriminalize Natural Psychedelics Passes State Legislature on the Heels of Phase 2 Data Showing Safety, Efficacy of Psilocybin for MDD
California is possibly on the verge of signing a bill that would decriminalize the personal possession of natural psychedelics for those aged 21 years and older.
FDA Approves IND for CT7439, a Novel CDK12/13 Inhibitor to Treat Multiple Types of Advanced Solid Tumors
The CDK12/13 inhibitor will be tested for efficacy and safety in patients with advanced solid tumors, such as breast, ovarian, and Ewing Sarcoma.
Increased Vitamin D Intake Can Decrease Symptoms of Depression, Anxiety
Although findings indicate a relationship between vitamin D and mood disorders, further research is needed to clarify efficacy of specific vitamin D levels, as well as supplement dose and form.
Phase 3 Study Demonstrates Amivantamab-vmjw is Safe, Effective in Improving PFS in Patients With NSCLC
Patients who received amivantamab plus chemotherapy or amivantamab without chemotherapy presented better outcomes compared to chemotherapy alone.
Current HIV-1 Vaccine Designs Aim to Improve Breadth of Broadly Neutralizing Antibodies
Combining T and B cell vaccines could induce a strong enough immune response and protect against HIV-1 infection, although the science is not fully developed.
Phase 3 Trial Results Show Tisotumab-Vedotin Improved OS in Adult Patients With Recurrent or Metastatic Cervical Cancer
In addition to overall survival, main efficacy outcomes, such as progression-free survival, objective response rate, and time to response, were compared to chemotherapy alone.
Phase 3 Trial Results Show Adjuvant Alectinib May Reduce Recurrence in Early-Stage ALK-Positive NSCLC
If approved, alectinib would be the only anaplastic lymphoma kinase inhibitor to show reductions in risk of recurrence or death for those with early-stage lung cancer.
Study Finds Inadequate Emotional Support, Lower Health-Related Quality of Life, Increased Odds of Depression in Adults With Gastrointestinal Cancers
Additional research is needed to further evaluate whether adequate emotional support is linked to improvements in health-related quality of life in adults diagnosed with other cancer.
Study: COVID-19 Pandemic Associated With Worse Treatment, Outcomes in Patients With Acute Myocardial Infarction
Although the pandemic has negatively influenced the care that patients with cardiovascular conditions receive, the study authors found that there were not significant inequities regarding patients’ race.
Insufficient Data on Cannabis Products’ Reduction of Symptoms in Pediatric Cancer, Further Research Necessary
Despite the limited data, prior research indicates there are no serious cannabis-related adverse effects in pediatric patients.
Upcoming Phase 3 Clinical Program Will Examine Efficacy of Oral PCSK9 Inhibitor MK-0616 in Patients With Hypercholesterolemia
The phase 3 clinical program, CORALreef, consists of 3 trials and is likely the first of its kind for an oral PCSK9 inhibitor, according to the study authors.
Patients With Cancer Engaging in Administrative Payment Tasks May Choose to Delay or Not Adhere to Treatment
Patients with cancer and survivors of cancer that had engaged in administrative tasks to effectively estimate costs or pay for care was associated with an 18% increase in cost-related treatment delays or treatment nonadherence.
CDC Recommends Beyfortus for Routine Use to Protect Infants, Young Children Against Respiratory Syncytial Virus
Nirsevimab (Beyfortus) is the first respiratory syncytial virus (RSV) preventative drug to be approved by the FDA, and can protect infants through their first RSV season for up to 5 months.
Study Suggests Lorazepam May Increase Odds of Pancreatic Cancer Progression, Death
Patients with pancreatic cancer who took benzodiazepine lorazepam had a shorter progression-free survival than those who took benzodiazepine alprazolam.
Retatrutide Treatment Results in Reductions in Body Weight Compared to Placebo
Most participants who received retatrutide lost a considerable amount of body weight; however, individual results varied given the diversity of obesity.
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