CLINICAL ROLE -
Ribociclib With Endocrine Therapy Improved Invasive Disease-Free Survival in Patients With Early Breast Cancer
Compared to endocrine therapy alone, the combination of ribociclib and endocrine therapy lowered the risk of cancer recurrence in patients with early breast cancer by 25.2%.
Pembrolizumab With Chemotherapy Before Surgery Significantly Improves Response Rate in Patients With Breast Cancer
Phase 3 Trial Results Support Subcutaneous Nivolumab Treatment for Patients With Metastatic ccRCC
Subcutaneous nivolumab had demonstrated noninferiority of Cavgd28, Cminss, and ORR compared to the intravenous form of treatment.
Nasopharyngeal Swabs Most Sensitive for Pneumococcal Detection in Infants
Study authors suggest that saliva samples can be a complementary testing method to provide additional information on pneumococcal carriage and serotypes that may be undetected by nasopharyngeal testing.
Similar Pneumococcal Serotype-Specific Responses Observed Between Shared Serotypes in Patients Administered PCV13, PCV15 Vaccines
Study data suggest that both vaccines induce similar functional antibody responses against pneumococcal serotype 3.
Expert: Celebrating Pharmacists’ Role in Health Care, Changes in the Profession
The assistant program director at Mayo Clinic discusses the significance of pharmacists’ role in health care, changes throughout the industry, and her passion for mentoring pharmaceutical students.
Study Results Indicate Precision Therapies Make Up Approximately Half of FDA-Approved Oncology Drugs
This finding underlines the need for methods that address multiple genomic alterations and targeted therapies effective in tumors driven by variations in suppressor genes or transcription factors.
FDA Approves Tenapanor for Chronic Kidney Disease
Twice-daily tenapanor tablets are recommended for patients with chronic kidney disease who are on dialysis, unresponsive or intolerant of any dose of a phosphate binder therapy.
Alternative Model for Lung Cancer Screening Shows Higher Sensitivity Than Current Model
PLCOm2012 uses additional parameters to predict the risk of lung cancer and was found more effective when identifying both Indigenous and non-Indigenous individuals with lung cancer.
Older Adults Who Disagree With Deprescribing Medication More Interested in Additional Communication, Alternative Strategies
According to the authors, identifying the degree of disagreement with physicians’ deprescribing recommendations can improve the communication among older adults and their physicians.
Likelihood of Depression Is High in Patients With Cancer Who Experience Serious Adverse Events
Mental health treatment may be necessary when SAEs occur.
FDA to Create Digital Health Advisory Committee By 2024
The committee will help the FDA address issues related to digital health technologies, including artificial intelligence, virtual reality, cyber security, and patient-generated health data.
Rebyota Found Safe, Effective in Preventing Recurring Clostridioides Difficile Infection
Treatment-emergent adverse events associated with Rebyota for Clostridioides difficile infection were more prevalent in those with renal comorbidities than in those without and were moderate in severity as well as related to pre-existing conditions.
Study: Individuals With Inflammatory Disease Did Not Have Higher Risk of VTE Following COVID-19 Infection
The study results also indicate no significant difference of venous thromboembolism risk between individuals with immune-mediated inflammatory diseases and individuals without.
Uptake, Acceptability of HIV Pre-Exposure Prophylaxis Treatment Influenced by Knowledge, Perception of Risk in MSM
Although increased knowledge and understanding could increase uptake and acceptability of pre-exposure prophylaxis for HIV, action is needed to remove barriers and improve accessibility.
Phase 3 Trial Findings Support Nivolumab Treatment in Multiple Cancer Types
Trial data bolster the role of nivolumab and nivolumab-based combinations in both early and metastatic stages of multiple cancer types, especially in patient groups with high unmet needs.
Follow-Up Survey Indicates Cancer Centers Continue to Experience Chemotherapy Shortages
Larger institutions have continued to treat patients who needed carboplatin or cisplatin; however, the survey results don’t include smaller cancer centers that may face access challenges.
Study: Antibiotic Exposure During Pregnancy Associated With Increased Risk of Childhood Respiratory Allergies
The study authors note that it is important for expectant mothers to use antibiotics appropriately and when necessary, as well as monitor their child after birth.
Study Uses Data to Examine Mental Health Trends in Patients With HIV Before, After COVID-19 Outbreak
Study shows that interventions may help to personalize care that meets the individual needs of patients with HIV and to improve mental health outcomes.
Nirmatrelvir, Ritonavir Treatment Associated With Reduced Risk of COVID-19 Hospitalization, Death in Extremely Vulnerable Patients
Study authors suggest that immunocompromised patients may greatly benefit from nirmatrelvir and ritonavir; however, there was no significant benefit shown in lower-risk patients.
Navya-PPT May Help Patients With Early Breast Cancer Choose Between Breast-Conserving Surgery, Mastectomy
Not only did the Navya-Patient Preference Tool help patients with decision-making, but groups who used the tool were more likely to receive their preferred form of surgery.
Metformin Monotherapy With GLP1RA, SGLT2I, DPP4I More Effective Than Sulfonylurea When Managing Diabetes
Compared with sulfonylurea, these add-on treatments were also associated with fewer diabetes-related cardiovascular and renal complications as well as avoiding hypoglycemia.
Study Finds Increased GI Cancer Risk Among Individuals With Overweight, Obese BMIs Throughout Adulthood
The results also indicate an association with increased risk of colorectal and noncolorectal gastrointestinal cancers as body mass index increases over time.
Expert: Reaching Out for Healthy Women, A Data-Driven Approach to Helping Women Access Health Care
The manager of patient support services at St. Luke’s Cancer Center discusses the significance of Reaching Out for Healthy Women and how female patients can receive support from this initiative.
Study Results Indicate Palliative Care Less Common Among Racial Minority Patients With Metastatic Breast Cancer
Lack of awareness, cultural beliefs, and physician preferences may influence whether minority patients receive palliative care during metastatic breast cancer treatment.
Study Finds Enterococci Enhance C. Difficile Pathogenesis, Promoting Colonization
Not only did enterococci promote C. difficile pathogenesis, but it was also shown to provide fermentable amino acids, facilitating its virulence agitated gastrointestinal tracts.
Study Shows Association Between Alpelisib Treatment, Hyperglycemia in Patients with Metastatic Breast Cancer
The study authors suggest that after initiating alpelisib, patients should be proactive by improving glycemic status to reduce the risk of developing hyperglycemia.
Analysis Indicates Sleep Duration, Health Influenced by Environmental Changes
Environmental factors may change sleep patterns over time, which subsequently affects rapid eye movement sleep.
Trial Results Find Enfortumab Vedotin-ejfv, Pembrolizumab Combination Effective in Urothelial Cancer
The combined enfortumab vedotin-ejfv and pembrolizumab treatment is recommended for patients with locally advanced or metastatic urothelial cancer who are ineligible for cisplatin-containing therapy.
Intervention with Supplemental Creatine Found Effective, Safe for Symptom Reduction After COVID-19 Infection
At a 6-month follow-up, supplemental creatine intervention significantly improved scores for fatigue symptoms and tissue bioenergetics related to COVID-19 infection.
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