Skin Cancer

Approximately 40% of patients with stage IV melanoma have brain metastases at diagnosis.

Shannon M. Rotolo, PharmD, BCPS, examines the role dupilimab plays as a disease-modifying therapy for the treatment of moderate-to-severe atopic dermatitis, and Peter Lio, MD, considers the unmet needs that exist within atopic dermatitis therapy.

Pembrolizumab (Keytruda) can be used for multiple cancer types, including melanoma, non-small cell lung cancer, and head and neck squamous cell cancer.

The investigators said that these cells, referred to as lymph node resident memory T cells, have been demonstrated to counteract the spread of melanoma in mice.

Cemiplimab is a recombinant human immunoglobulin G4 monoclonal antibody that binds to PD-1 and blocks its interaction with PD-L1 and PD-L2.

Relatlimab is the first LAG-3-blocking antibody to demonstrate a clinical benefit for patients with melanoma in phase 3 data.

Phase 3 trial results show that the drug reduced the risk of death or reoccurrence by 35% for individuals with high-risk disease compared with the placebo.

Survey participants saw potential for immunotherapy use in earlier stages of several diseases, including melanoma, lung cancer, and bladder or urothelial cancer.

BCC is the most common form of skin cancer and is typically treated with surgical excision. However, excision can be a costly and burdensome treatment, especially for patients with multiple BCC lesions, according to the study.

The FDA has previously granted Orphan Drug designation to nemvaleukin for the treatment of mucosal melanoma.

AQP-modulating agent discovery has proved challenging, but many powerful AQP3 permeating molecules have been identified.

The FDA has granted Orphan Drug Designation (ODD) to alrizomadlin (APG-115, Ascentage Pharma) for the treatment of stage IIB-IV melanoma.

Many individuals underestimate the importance of protecting their skin from the sun.

Patients may consult with their pharmacist regarding appropriate protection methods and treatment options available for common summer skin ailments.

A recent study proved community pharmacies are model settings for skin cancer prevention education in rural communities with insufficient access to health care services.

The approval is based on results from the phase 2 KEYNOTE-629 trial, which found an objective response rate of 50% in adults with recurrent, metastatic, or locally advanced cutaneous squamous cell carcinoma.

Pharmacists’ vast health care knowledge and community accessibility makes them ideal patient liaisons.

The current study analyzed human tumor samples from 6 cancer types: liver, melanoma, colorectal, non-small lung, head and neck, and breast cancer.

Melanoma forms when pigment-producing cells called melanocytes mutate and multiply uncontrollably.

In England, incidence rates of the skin cancer cutaneous malignant melanoma were found to have increased by more than 550% among males and 250% among females since the early 1980s.

The FDA has granted toripalimab a fast track designation for use in the frontline treatment of patients with mucosal melanoma.

Pvsripo is a novel immunotherapy that activates patients’ innate and adaptive immune system to enable anti-tumor response and establish immunologic memory to prevent the recurrence of cancer.

Counseling patients on possible adverse effects that impact skin health can help patients prepare for serious or cosmetic impacts.

To analyze digital images of metastatic tumors of melanoma, the researchers used computer algorithms, or deep convolutional neural networks (DCCN), to identify patterns associated with treatment response.

The researchers isolated human primary keratinocytes from the skin of patients with non-melanoma skin cancers.

More than half of high-risk patients with resected, stage III BRAF V600-mutated melanoma who were treated with dabrafenib and trametinib were alive and relapse-free at 5 years.

This activity is supported by an educational grant from Merck Sharp & Dohme Corp..

Officials with the FDA have approved atezolizumab plus cobimetinib and vemurafenib for the treatment of patients with BRAF V600 mutation-positive advanced melanoma.

Pharmacy Times® spoke with Jennifer Craig, PharmD, CSP, about Skin Cancer Awareness Month and the importance of skin care.

"Approximately 40% of melanomas are considered to be ‘cold,’ meaning that they lack sufficient infiltration of immune cells within the tumor."