C. difficile

Antibiotics that were found to be most commonly associated with clostridium difficile infection are piperacillin/tazobactam, meropenem, vancomycin, ciprofloxacin, ceftriaxone, and levofloxacin, according to a recent study.

The novel antibiotic combines aztreonam, a monobactam β-lactam, with avibactam, a broad-spectrum β-lactamase inhibitor.

Patient education and counseling play a critical role in preventing C. difficile recurrence, and pharmacists are uniquely positioned to provide treatment recommendations, educate patients and health care providers, optimize transitions of care, and reduce the risk of recurrent CDI.

Experts provide practice pearls for educating patients on and using FMTs for the management of CDI.

Joseph Reilly, BS, PharmD, BCGP, reviews the positive economic impact of use of live-jslm for treatment of CDI in a hospital setting.

Experts comment on the measures that need to be taken to prevent or control the spread of CDI in the healthcare setting.

Randomized clinical trials still showed that microbiota restoration is significantly more effective than antibiotics for recurrent Clostridioides difficile infection.

Rebyota is a live biotherapeutic product that is unfamiliar to many pharmacists and other health care providers with different steps in the eventual administration process.

Candace Cotto, RN, and Andrew Skinner, MD, discuss barriers to use of FMTs in managing CDI, highlighting clinician and patient education.

Experts comment on insurance coverage as a factor for the broader use of FMTs for the management of CDI.

In Greece, the stark increase in Clostridioides difficile (C. diff) incidence cannot be explained by a rise of antimicrobial use during the pandemic.

Candace Cotto, RN, reviews the process of incorporating fecal microbiota, live-jslm treatment into clinical practice, what patients can expect, and the room sanitation process after the procedure.

The results of a recent study suggest that a testing policy change for C. difficile could decrease the risk of additional infections and the corresponding economic burden on the hospital.

Supportive nurse managers and supervisors as well as nurses’ involvement in organizational governance may help lower hospital-onset Clostridioides difficile infection in acute care hospitals.

Treatment-emergent adverse events were reported in a similar proportion of participants with recurrent Clostridioides difficile infection, both with and without immunocompromising conditions.

Patients with C. difficile who received clonal bacteria populations via biotherapeutic injection were able to repopulate their microbiota with commensal bacteria.

The infection causes diarrhea and inflammation of the colon, and it can be difficult to get rid of it.

Cephalosporin treatment is a risk factor of Clostridioides difficile infection.

Through 8 weeks after treatment, C. difficile recurrence in SER-109-treated participants was lower compared to placebo-treated participants.

Fecal microbiota transplantation may result in a slight reduction in serious adverse events, but the confidence intervals around the summary estimate were wide in immunocompetent adults with recurrent C. difficile infection.

Investigators use a large PCR-only data set to confirm that PCR CT can predict recurrence-free survival, using Cox proportional hazards regression.

The 2 most hypervirulent strains of Clostridioides difficile are associated with the consumption of pork and shellfish.

These are used to help reduce inappropriate testing, where an expert consults with medical directors of infection prevention and control for a test-order override.

Not only are pharmacists easily accessible to the public, they are also highly visible as a source for travel immunization services.

Similarities between the symptoms of Clostridioides difficile infection and Crohn disease may cause confusion for health care providers.