Brain Health

Hypomyelination with atrophy of the basal ganglia and cerebellum is the most severe form of TUBB4A leukodystrophy that currently has no curative treatment.

The dynamic reconfigurations in individuals taking antidepressant were higher than in non-users and controls, with no significant differences between those with MDD or an anxiety disorder.

Sustained cognitive improvement is likely a result of lower inflammation, remission of comorbidities, higher physical activity, and better mood.

The authors emphasize that further research on a diverse population that focuses on the role of duration and lifestyle choices and neuroinflammatory markers should be performed.

Despite the tool’s ability to predict efficacy of sertraline in patients with major depressive disorder, the investigators note that future research will seek to improve the algorithm.

The study authors noted that further research with larger populations should be conducted to boost the reliability and generalizability of the results.

Patients who took a multivitamin for 2 to 3 years showed improvements in global cognition and episodic memory compared with placebo.

The study authors note that to effectively implement tools, processes, and strategies within practices, the stigma surrounding cognitive impairment must be addressed.

The study used optogenetics to repeatedly activate and inhibit cells, revealing rapid changes in a protein called pyruvate dehydrogenase when cells were inhibited.

Providers can consider the patient’s medication history, comorbidities, or migraine type to help choose a first line treatment or refer the patient to specialized care.

Migraine headaches are considered a leading cause of disability around the world.

Migraines are not a one-size-fits-all condition, and there is no one-size-fits-all solution.

New sentences that had different linguistic properties than traditional sentences drove brain activity, according to the study authors.

The results from the preclinical trial can provide a new method of measuring dietary sources of nutrients in the tissue, but further research is needed to confirm the findings in the human brain.

Compared to placebo, a daily multivitamin showed consistent benefits in global cognition and episodic memory across a clinical trial and meta-analysis of 3 trials.

Benzodiazepines have proven effective in managing anxiety and insomnia, but they heighten risk of falls, cognitive impairment, functional decline, and mortality among older adults.

However, cognitive performance was not significantly worse than patients hospitalized for other conditions of a similar severity.

These patients have slow brain wave activity during wakefulness, which can reduce the firing of nerve cells to protect against the pathology of epilepsy.

Despite nearly one-third of reversible dementia cases being drug induced, cognitive safety is a neglected aspect of clinical trials.

Although personality was linked to cognitive performance on tests, it was not linked to dementia pathophysiology.

Patients with this genetic variant have impaired neuronal excitability, a trait that has been linked to malfunctional synapses.

Following acoustic stimulation intervention, many patients experienced a reduction in neurobehavioral symptoms.

An animal study shows that early-life stress may increase risk-taking behaviors in adulthood; in humans, this could translate to risk of substance use disorder.

Patients hospitalized for traumatic brain injury have different brain injury biomarkers and rates of glucose variation.

While manganese can sometimes be considered toxic, prenatal exposure may be linked to better memory at adolescence.

Person-centered care focuses on tailoring treatment plans, providing medication support, and ensuring access to resources that meet their unique needs.

A subcutaneous injection of ocrelizumab was markedly effective at suppressing brain lesions in patients with multiple sclerosis, according to data from a phase 3 trial.

Aducanumab, lecanemab, and donanemab are novel monoclonal antibodies designed to slow disease progression and hopefully have a positive impact in the field of Alzheimer disease management.

Use of antidepressants and other classes of prescription drugs can increase the risk of driving impairment compared to nonuse, so clinicians and pharmacists should review these risks with older adults.

“There is method to this madness” describes routines that affect adherence to medication regimens.