Brain Health

Although personality was linked to cognitive performance on tests, it was not linked to dementia pathophysiology.

Patients with this genetic variant have impaired neuronal excitability, a trait that has been linked to malfunctional synapses.

Following acoustic stimulation intervention, many patients experienced a reduction in neurobehavioral symptoms.

An animal study shows that early-life stress may increase risk-taking behaviors in adulthood; in humans, this could translate to risk of substance use disorder.

Patients hospitalized for traumatic brain injury have different brain injury biomarkers and rates of glucose variation.

While manganese can sometimes be considered toxic, prenatal exposure may be linked to better memory at adolescence.

Person-centered care focuses on tailoring treatment plans, providing medication support, and ensuring access to resources that meet their unique needs.

A subcutaneous injection of ocrelizumab was markedly effective at suppressing brain lesions in patients with multiple sclerosis, according to data from a phase 3 trial.

Aducanumab, lecanemab, and donanemab are novel monoclonal antibodies designed to slow disease progression and hopefully have a positive impact in the field of Alzheimer disease management.

Use of antidepressants and other classes of prescription drugs can increase the risk of driving impairment compared to nonuse, so clinicians and pharmacists should review these risks with older adults.

“There is method to this madness” describes routines that affect adherence to medication regimens.

Investigators said that these results were promising, indicating that trigonelline could help to alleviate cognitive decline associated with aging.

Maintaining a purpose in life has the potential to reduce apathy related to dementia and cognitive decline.

In clinical trials, lecanemab showed a reduction of amyloid beta plaque in patients with Alzheimer disease.

Testosterone may protect the brain against dementia pathology, but the association has not been proven.

Infections were associated with a 1.49-fold increase in the rate of dementia in both the short- and long-term rates, however, the increases were greater in the short term.

Symptoms of dementia can be difficult to differentiate from typical age-related behavior changes and other common and potentially curable conditions.

Failing to protect the elderly from disease has consequences beyond nursing homes.

In addition to improving risk evaluation in older adults at home, point-of-care testing may help clinicians manage patients with dementia who cannot communicate and those living in depopulated areas.

Heart health may influence long-term brain health as early as middle age.

This social determinant of health could have the same level of negative impact on health as the experience of racism, poverty, or low education.

The recent discovery could aid further research on the cause of Huntington’s disease and other inherited conditions.

UB-311 has shown to be well-tolerated with a durable antibody response in a previous phase 1 trial, and new results from a phase 2a study support its continued development.

Investigators aimed to determine whether liraglutide, an anti-obesity medication, could impact the learning process for individuals who had reduced insulin sensitivity due to obesity.

Sleep loss is known to impact key processes such as attention, cognition, learning, memory, metabolism, and immune function.

Key study finding shows associations between the beat frequency in the rhythmic stimulus in the frontal left sites of infant brains and pathways related to brain modulation and nucleotide levels.

Advancements in the development of amyloid-targeting monoclonal antibodies show promise for treating Alzheimer disease, but there have been concerns around cost, adverse reactions, and inequity of care for marginalized patients.

Unexpectedly, the highest increases in delirium compared to projections were in the 66 to 74 years of age group, which could have important personal and societal repercussions, such as earlier development of dementia.

Adults aged 80 years and older and those living in areas with worse economic conditions are more likely to receive potentially inappropriate medications in the outpatient setting, which may be associated with cognitive impairment.

Of the individuals that participated in the study, 65.3% reported hearing loss at 71 years and 96.2% reported hearing loss by 90 years.