Infusion Hesitancy and the Impact of Route of Administration of NSCLC Treatment Options in Patients’ Quality of Life

EP: 1.Overcoming Challenges in NSCLC Management From a Pharmacist’s Perspective

EP: 2.First-Line Focus: Molecular Testing and Guideline-Directed Therapy in EGFR-Positive NSCLC

EP: 3.Recent Clinical Trial Highlights for NSCLC Treatment

EP: 4.Integrating Clinical Trial Findings Into Everyday Pharmacy Practice

EP: 5.Barriers to Bridging Clinical Trial Data to Routine Pharmacy Practice

EP: 6.Enhancing Patient Care Through Multidisciplinary Team Collaboration in Management of NSCLC

EP: 7.Breaking New Ground: Emerging Therapies for Treatment of EGFR-Positive NSCLC

EP: 8.Balancing Treatment and Quality of Life: Adverse Events of First-Line Agents in NSCLC

EP: 9.Strategies to Minimize Toxicities, and the Pharmacist’s Role in Educating and Supporting Patients With NSCLC

EP: 10.Infusion-Related Reactions: Clinical Trials and Guideline-Driven Prophylaxis and Management Strategies for Patients Undergoing NSCLC Treatment

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EP: 11.Infusion Hesitancy and the Impact of Route of Administration of NSCLC Treatment Options in Patients’ Quality of Life

Impact of Evidence-Based Approaches on Treatment Implementation: Summary for Physicians

Infusion Hesitancy with High-Risk Agents

• Data from the SKIPPirr trial have significantly reduced physician hesitancy in prescribing amivantamab
• Enhanced premedication protocols have improved confidence among infusion nurses
• Institutions continue to block 8-hour appointments for cycle 1 day 1 and day 2 amivantamab patients
• Well-informed health care teams are better equipped to manage potential reactions

Oral vs IV Therapy Considerations

Oral Therapy Advantages

• Provides greater patient autonomy and sense of control
• Reduces frequency of clinical visits
• May improve quality of life by eliminating infusion appointments

Oral Therapy Challenges

• Reduced adherence in patients with limited social support or lower health literacy
• Less frequent monitoring may delay identification and management of adverse effects
• Patient hesitancy to report symptoms between visits can impact treatment efficacy

IV Therapy Considerations

• Regular clinic visits ensure consistent monitoring and adherence
• Travel burden for frequent appointments may decrease quality of life
• More immediate opportunity to address emerging adverse effects

Clinical Approach

• Treatment selection should involve thoughtful discussion about individual patient circumstances
• Assess potential barriers to adherence for both oral and IV options
• Consider patient preferences, distance to treatment center, and support systems
• Balance efficacy considerations with anticipated impact on quality of life

The ideal treatment approach requires individualizing therapy based on both clinical factors and patient-specific considerations.