Adverse Events of EGFR TKIs: Summary for Physicians
Based on the transcript, the most common adverse events associated with EGFR TKIs are:
Dermatologic Toxicities
- Acneiform rash: Typically affects face, upper chest, back, and shoulders
- More common in men than in women
- Can range from mild to severe with potential for superimposed infection
- Management varies by grade/body surface area affected
- Severe cases may require topical and oral antibiotics
- Dry skin: Requires regular moisturizing with creamy products
- Associated itching can disrupt sleep and impact quality of life
- Paronychia: Presentations include nail flaking, cracking, nail bed/cuticle inflammation
- Can progress to abscess formation and nail loss in severe cases
- Management options include vinegar soaks and dermatology referral
- Photosensitivity: Increased skin sensitivity to sunlight
Gastrointestinal Effects
- Diarrhea: Second most common adverse event
- Ranges from increased frequency with formed stool to loose/watery diarrhea
- Associated urgency significantly impacts quality of life
- Patients may limit activities due to unpredictability
Quality-of-Life Impact
- Dermatologic toxicities may cause embarrassment, leading to social isolation
- Diarrhea can restrict patients’ ability to leave home
- Both categories of adverse effects may necessitate dose adjustments
This summary highlights the importance of proactive symptom management to maintain treatment efficacy and patient quality of life.