Opinion|Videos|June 6, 2025
Addressing Critical Gaps in the Management of NSCLC and the Importance of the Next Wave of Treatment Advances
Author(s)Lauren Ledbetter, PharmD, BCOP
A panelist discusses how emerging research in non–small cell lung cancer (NSCLC) is focused on determining the most effective neoadjuvant/adjuvant approaches combining chemotherapy with immunotherapy, addressing tumor heterogeneity through potential combinations of targeted therapies, and investigating mechanisms of immunotherapy nonresponse to improve patient outcomes.
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Episodes in this series
Current Research Challenges
- Early-stage NSCLC:
- Multiple FDA approvals for neoadjuvant/adjuvant chemoimmunotherapy; awaiting mature data to establish optimal approach
- Tumor heterogeneity: Multiple targetable mutations often present; no current data on combining targeted therapies
- Immunotherapy nonresponders: Research needed to understand mechanisms of nonresponse and identify additional targets
- Focus on minimizing toxicity exposure when benefit cannot be guaranteed
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