Chronic Kidney Disease

Treatment with Injectafer significantly improved exercise capacity compared to placebo in a randomized clinical trial in adult patients with heart failure.

In addition to 2 FDA-approved options, several clinical trials are investigating other potential treatments for immunoglobulin A nephropathy.

Studies show that patients who had pharmacists as part of their transplant-related care had a significant improvement in clinical outcomes.

A linear mixed-effect model for repeated estimated glomerular filtration rate measurements at baseline and a follow-up visit, up to 5 years after baseline, shows results.

It is important for pharmacists to understand implications related to drug clearance to maximize therapeutics in patients with kidney disease.

Finerenone is a first in class nonsteroidal mineralocorticoid receptor antagonist indicated in adults with chronic kidney disease associated with type 2 diabetes mellitus.

Study participants without co-pays were slightly more likely to take their medications as prescribed for several medication classes.

The 2022 American Heart Association, American College of Cardiology, and Heart Failure Society of America guidelines recommend SGLT2 inhibitors for nearly all patients in cardiovascular practice.

Pharmacists play a vital role in ensuring that patients can afford their medications, either by advising them on more affordable options or working with insurers and prescribers to find cheaper alternatives.

Sparsentan decreased proteinuria by nearly 50% in patients with IgA nephropathy, which may slow kidney function decline.

Letermovir is the only drug approved for prophylaxis of cytomegalovirus (CMV) infection for patients who are CMV-seropositive and have received an allogeneic HSCT.

Patients with heart failure are at a significant risk of cardiorenal diseases, highlighting the need for improved treatments and cost management.

The knowledge of clinical pharmacists can help protect kidney function and prevent the development of acute kidney injury in ICU patients.

Daprodustat (Jesduvroq, GSK) is the first oral hypoxia-inducible factor prolyl hydroxylase inhibitor to gain approval in the United States.

Providers must carefully prescribe, monitor, and adjust renally relevant drug lists in patients with chronic kidney disease to prevent progression.

A community-based multidisciplinary team can have a significant impact addressing health disparities and diabetes management.

In a phase 3 trial, empagliflozin significantly reduced the risk of kidney disease progression or cardiovascular death in adults with chronic kidney disease by 28% compared with placebo.

The oral SGLT2 inhibitor has been shown to reduce blood sugar and improve glycemic control as an adjunct to diet and exercise.

Data from a randomized clinical trial supports previous clinical findings on SGLT2 inhibitors and their ability to slow the progression of chronic kidney disease.

The report highlights the growth of personalized medicines with improved efficacy for rare, previously untreatable diseases.

The protein, called suPAR, has long been known to be a biomarker for poor outcomes and disease progression in both kidney disease and cardiovascular disease.

Investigators hope findings of study in mice help improve treatment for individuals with acute kidney injury.

Age was a contributing factor of chronic kidney disease and albuminuria in patients with type 1 and type 2 diabetes.

A randomized study of renin-angiotensin system inhibitors in advanced chronic kidney disease found that patients who continued receiving therapy had similar outcomes to those who discontinued treatment.

Dapagliflozin (Farxiga) found effective in lowering the risk of hospitalization for patients with chronic kidney disease, with or without a diagnosis of type 2 diabetes, and increased the number of days alive and out of the hospital.

Atrasentan has been found to lower albuminuria, which correlates with reductions in low-density lipoprotein cholesterol and triglycerides.

Inhibiting the lipid kinase VPS34 may improve the treatment of diseases such as diabetes and kidney cancer.

Pharmacists play a significant role in the comprehensive management of this condition through education, intervention, and monitoring.

Dapagliflozin and standard of care found to slow the decline in kidney function and lower the incidence of kidney failure.

Daprodustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor being evaluated for the treatment of anemia of chronic kidney disease in adult patients on and not on dialysis.