TrumpRx Launches, Offering Cash-Paying Patients Discounted Drugs

On February 5, 2026, President Donald Trump unveiled TrumpRx.gov, a new platform designed to aggregate direct-to-consumer (DTC) purchasing platforms for key prescription drugs for patients who are uninsured and pay cash. Over 40 drugs have been listed on the site at launch, including fertility and weight loss drugs, with plans to add more in the future.^1-4

Patients cannot purchase drugs directly through TrumpRx. Rather, like GoodRx, a patient can search for a drug on the platform and find the savings they stand to achieve if they use a manufacturer coupon or purchase the drug directly from a manufacturer. Patients with insurance cannot purchase drugs through TrumpRx; however, a disclaimer is featured above each drug listed on the website, noting that the price is for “out-of-pocket” payments and that patients should check their copay first, since the price may be even lower.^1,2

Which Drugs Are Included on TrumpRx?

Medications available on TrumpRx at launch include oral semaglutide (Wegovy; Novo Nordisk), injectable semaglutide (Ozempic, Wegovy; Novo Nordisk), tirzepatide (Zepbound; Eli Lilly and Company), follitropin alfa injection (Gonal-F; EMD Serono), cetrorelix acetate for injection (Cetrotide; EMD Serono), and insulin lispro (Humalog; Eli Lilly and Company).¹

The platform is based off a series of agreements the Trump Administration has struck with pharmaceutical companies. Broadly, the companies have agreed to launch DTC purchasing platforms for uninsured patients on Medicaid to access critical drugs in their pipeline that are often priced at astronomical amounts through insurance. Most Favored Nation pricing, which is a push from the White House for pharmaceutical companies to price drugs in the United States at amounts comparable to often-lower prices in other high-income countries, is the basis for TrumpRx.⁵

The Trump Administration emphasizes significant savings on drugs for conditions like infertility or overweight and obesity. However, the prices for these high-demand medications—especially glucagon-like peptide-1 medications—have been slowly declining in price since their launch. Experts from The New York Times and ABC News note that most of the drugs featured on the site are already covered through insurance, with some available as generics from competitors.^2,3

For some drugs featured on TrumpRx, such as oral semaglutide, a coupon offer displayed through the platform allows a patient to receive a medication from “local pharmacies on a nationwide basis” through the platform. The platform provides a list of pharmacies that can dispense the drug and indicates whether it is widely available at retail pharmacies or can only be dispensed at a mail-order specialty pharmacy. A patient can then call or visit the pharmacy, present their coupon, and receive the drug at the discounted price.¹

Other drugs featured on the website, like albuterol/budesonide (Airsupra; AstraZeneca), tirzepatide (Zepbound; Eli Lilly and Company), and dapagliflozin/metformin (Xigduo XR; AstraZeneca) must be purchased directly through the manufacturer’s website. In these cases, a link is provided underneath the drug for a patient to access the manufacturer’s DTC platform.¹

Reactions to the Announcement

Some organizations and groups have celebrated the launch, heralding the platform as a step toward lower prices for Americans. However, it remains unclear exactly how much patients can expect to save when using TrumpRx.

“Today marks a monumental step in transforming drug pricing and making prescription drugs more affordable for the American people, particularly for those without insurance,” said Carl Schmid, executive director of the HIV+Hepatitis Policy Institute, in a news release. “For those who do have insurance, TrumpRx may not always be the best option.”⁶

Democrats have raised concerns about the platform, arguing that it creates more confusion for patients and will ultimately benefit Trump.

“TrumpRx is nothing more than a glorified coupon book, and it will advance the Republican agenda to undermine affordable health care for American families,” said Senate Finance Committee Ranking Member Ron Wyden (D-Ore), in a statement. “Americans don’t want to jump through yet another health care hoop on Trump’s self-serving website. Patients deserve to leave the doctor’s office, go to the pharmacy, and pay a low price for their medicine—no coupon needed.”⁷

As TrumpRx continues to roll out, its real impact on drug affordability remains uncertain. The platform may offer meaningful savings for some uninsured patients, particularly for high-cost or hard-to-access therapies, but it also adds another layer to an already complex drug-pricing landscape. As manufacturers expand their direct-to-consumer programs and the administration promotes the site as a landmark shift, patients, providers, and policymakers will be watching closely to see whether TrumpRx delivers substantial benefits or simply reshuffles existing options without addressing the underlying drivers of high prescription drug costs.

REFERENCES

1. TrumpRx. Accessed February 6, 2026. https://trumprx.gov/

2. Robbins R, Sanger-Katz M. Trump’s online drugstore opens for business. The New York Times. Published February 5, 2026. Accessed February 6, 2026. https://www.nytimes.com/2026/02/05/health/trumprx-online-drugstore-prices.html

3. Hutzler A, Wang S, Neporent L, Stoddart M. Trump unveils TrumpRx website he says will help Americans buy lower-priced prescription drugs. ABC News. Last Updated February 6, 2026. Accessed February 6, 2026. https://abcnews.go.com/Politics/trump-unveil-trumprx-website-americans-buy-lower-priced/story?id=129895605

4. President Trump launches TrumpRx.gov, delivering massive, immediate savings to millions of Americans. The White House. News Release. Released February 5, 2026. Accessed February 6, 2026. https://www.whitehouse.gov/articles/2026/02/president-trump-launches-trumprx-gov-delivering-massive-immediate-savings-to-millions-of-americans/

5. Halpern L. What pharmacies should know about most favored nation as drug prices continue to rise. Pharmacy Times. Published January 30, 2026. Accessed February 6, 2026. https://www.pharmacytimes.com/view/what-pharmacists-should-know-about-most-favored-nation-as-drug-prices-continue-rise

6. TrumpRx shakes up drug pricing by bypassing middlemen. News release. HIV+Hepatitis Policy Institute. February 5, 2026. Accessed February 6, 2026. https://hivhep.org/press-releases/trumprx-shakes-up-drug-pricing-by-bypassing-middlemen/

7. Wyden statement on TrumpRx announcement. United States Senate Committee on Finance. February 6, 2026. Accessed February 6, 2026. https://www.finance.senate.gov/ranking-members-news/wyden-statement-on-trumprx-announcement