Opinion|Videos|March 27, 2025

Monitoring Strategies for Managing ADC Toxicities in mBC

Name: Monitoring Strategies for Managing ADC Toxicities in mBC
Uploaded: 2025-03-27T12:00:00.000Z
Duration: 5 min 12 s
Description: Monitoring Strategies for Managing ADC Toxicities in mBC

Author(s)Heather Moore, BCOP, CPP, PharmD
Jodi Taraba, PharmD, MS, BCOP

Panelists discuss how pharmacists should monitor neutropenia, diarrhea, and mucositis from sacituzumab govitecan (SG); interstitial lung disease (ILD) and neutropenia from trastuzumab deruxtecan (T-DXd); and neutropenia and ILD from datopotamab deruxtecan (Dato-DXd). Proactive management is essential for patient safety.

Video content above has been prompted by the following:

Toxicity management is critical for patients on antibody-drug conjugates (ADCs). What are the most important ADC-related AEs that pharmacists should monitor (eg, neutropenia, diarrhea, ILD, mucositis) for T-DXd, SG, and Dato-DXd?

Stay informed on drug updates, treatment guidelines, and pharmacy practice trends—subscribe to Pharmacy Times for weekly clinical insights.

Subscribe Now!

Understanding the Risk of Second Primary Cancers After Early Breast Cancer
September 16th 2025
Common Challenges Encountered When Discussing the Shingles Vaccine with Patients
September 16th 2025
Encouraging Successful Completion of the Shingles Vaccine Series
September 16th 2025
Advancing Precision Immunotherapy in Triple-Negative Breast Cancer Through Plasma Proteomics
September 8th 2025
A Pharmacist’s View of Emerging CML Treatment
September 4th 2025
Potential for Precision: Exploring Targeted Therapies in mCRC Care
September 4th 2025

Latest CME

On-Demand Webinar

BURST Expert Illustrations and Commentaries™: Exploring the Mechanistic Rationale for CSF-1R– Directed Treatment in Chronic GVHD

1.0 Credit / Hematologic Cancer, Oncology

Monitoring Strategies for Managing ADC Toxicities in mBC

Newsletter

Related Articles

Latest CME

BURST Expert Illustrations and Commentaries™: Exploring the Mechanistic Rationale for CSF-1R– Directed Treatment in Chronic GVHD

From Strict Avoidance to Tailored Therapies: Transforming Food Allergy Care

The Evolving Strategies for Managing nAMD and DME: Empowering Managed Care Decisions for Improved Patient Outcomes

The Essential Role of Pharmacists in Improving Influenza Vaccination Coverage: Strategies to Increase Vaccine Uptake and Optimally Utilize Available Vaccines

The Role of Pharmacists in Pneumococcal Prevention: Strategies to Improve Vaccine Uptake

Collaborating Across the Continuum™: Identifying and Preventing Hepatic Encephalopathy in Long-Term Care Settings

The Latest Updates and Pharmacist Perspectives on RET Inhibitors in Non‒Small Cell Lung Cancer

Balancing the Burden of Moderate to Severe Atopic Dermatitis in Pediatric Patients: Navigating the Use of Targeted Biologic Therapies and Caregiver Challenges

Glucagon for Diabetes: Overcoming Barriers for Optimal Management in the Long-Term Care Setting

Insights in Influenza Immunization: The Long-Term Care Pharmacist’s Role in Improving Health Outcomes in At-Risk Populations and Vaccine Uptake

Managing Schizophrenia: Evidence-Based Care and Optimizing Value of New and Emerging Therapies

Transforming Small Cell Lung Cancer Management With DLL3-Targeted Therapies

Cytokine Release Syndrome With Bispecific Antibodies: A Pharmacist's Guide to Safe Management

Enhancing Endometrial Cancer Management: Highlights of Molecular Insights, Treatment Approaches, and Toxicity Management

Closing Gaps in CLL Care: Managed Care Insights and Strategies

Enhancing Safety in Cancer Care: Expert Guidance on Toxicity Management of HER2, TROP2, and HER3-Targeted Antibody-Drug Conjugates

Exploring the Role of Glucagon Like Peptide Receptor 1 Agonists (GLP-1RA) in the Treatment of Obesity (Pharmacist Credit)

A Pharmacist's Guide to the Safe and Effective Management of BTK and BCL-2 inhibitors in Chronic Lymphocytic Leukemia

Charting the Course: The Pharmacist's Role in Safeguarding Patients From Immune-Related Adverse Events

Patient Safety and Reporting Errors: A Guide for Pharmacists and Technicians (Pharmacy Technician Credit)

Patient Safety and Reporting Errors: A Guide for Pharmacists and Technicians

Advancements in Extensive-Stage Small Cell Lung Cancer Therapy: Integrating Clinical Evidence to Fill Gaps in Care

Overview and Burden of Migraine

The Evolving Treatment Landscape of Migraine

Mastering Hypertrophic Cardiomyopathy: Cutting-Edge Therapies for Better Outcomes

The Impact and Role of Pharmacists in the Management of Specialty Therapies

ASH Annual Meeting Coverage: Highlighting the Recent Updates in TKI Use in the Treatment of CML – Insights and Application for Managed Care

Exploring Advances in the Management of DOAC-Associated Bleeding With Reversal Agents: Role of the Health-System Pharmacists

Combating Opioid Overdoses: The Impact of Pharmacist-led Counseling and Dispensing of Opioid Reversal Agents

Multidisciplinary Perspectives and Patient-Centered Approaches in Newly Diagnosed Multiple Myeloma

New and Approved: FDA’s 2024 Drug Lineup

Innovations in Medicine: 2024 Lineup of New and Approved Specialty Drugs

Empowering Patients With COPD: The Pharmacist's Role in Personalized Treatment Strategies

Implementing Updated RSV Vaccination Recommendations for Older Adults: RSV Case Discussion (Pharmacy Technician Credit)

Implementing Updated RSV Vaccination Recommendations for Older Adults: Introduction and Disease Burden (Part 1)

Implementing Updated RSV Vaccination Recommendations for Older Adults: Considerations for the Pharmacist (Part 3)

Implementing Updated RSV Vaccination Recommendations for Older Adults: Considerations for the Pharmacist (Pharmacy Technician Credit)

Implementing Updated RSV Vaccination Recommendations for Older Adults: Incorporating ACIP Guidelines (Pharmacy Technician Credit)

Implementing Updated RSV Vaccination Recommendations for Older Adults: Introduction and Disease Burden (Pharmacy Technician Credit)

Navigating Diabetes: A Guide to Effective Oral Treatments

Advancing Acute Pain Care: Breakthrough Non-Opioid Therapies and the Pharmacist's Critical Role

Hyperlipidemia Overview and the Clinical and Economic Burden

Best Practices for Management of Hyperlipidemia: A Focus on Guidelines and Patient Adherence

The Role of the Pharmacist in the Management of Hyperlipidemia

Improving Patient Outcomes in Seasonal and Perennial Allergic Conjunctivitis

Improving Patient Outcomes in Seasonal and Perennial Allergic Conjunctivitis (Pharmacy Technician Credit)

Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care

Beyond the Spots: Management of Measles

Leveraging Managed Care to Optimize Patient Outcomes: Integrating Novel Treatments in Schizophrenia

Overcoming Operational and Clinical Barriers in Multiple Myeloma: Managed Care Strategies for Antibody-Based Regimens

Exploring Therapeutic Advances in Myelofibrosis and Key Considerations for Effective Management

Optimizing the Uptake of Long-Acting Injectables in HIV Treatment and Prevention: Considerations for Managed Care

Evaluating the Effectiveness and Value of Novel Nonhormonal Treatments in the Management of Menopause-Related Vasomotor Symptoms

Navigating the Changing Treatment Paradigm of Metabolic Dysfunction-Associated Steatohepatitis: A Guide for Managed Care Pharmacists

Harnessing Data-Driven Insights and Innovations to Enhance AMD and DME Management: Strategic Approaches for Managed Care

Transforming Lymphoma Treatment With Bispecific Antibodies: Practical Solutions for Oncology Pharmacy Teams

Maximizing Safety With Antibody-Drug Conjugates: Essential Practices for HER2, Trop-2, and HER3 Treatments

Expanding Access to Antibody-Based Regimens in Relapsed/Refractory Multiple Myeloma

Beyond the Prescription: Tackling Social Isolation for Better Health (Pharmacy Technician Credit)

Exploring ATTR Phenotypes and Identifying Appropriate Opportunities for Pharmacists to Intervene

Chronic Obstructive Pulmonary Disease and Inflammation: Practical Approaches to Integrating Biologic Therapy

Addressing the Burden of Hemolysis in Paroxysmal Nocturnal Hemoglobinuria: The Pharmacist's Contribution to Patient Care

Directions in Oncology Pharmacy® 2025: Midwest

Directions in Oncology Pharmacy® 2025: Southwest

From Testing to Treatment: Empowering Pharmacists to Overcome Barriers and Optimize Biomarker-Driven Care

Infectious Disease Day of Education 2025

Clinical Presentation of Hyperglycemia With PI3K and AKT Inhibitors

Multidisciplinary Insights to Enhance Biomarker Testing Practices in Non-Small Cell Lung Cancer

Directions in Oncology Pharmacy® 2025: West Coast

The Expanding Therapeutic Landscape in IgA Nephropathy: Translating New Clinical Evidence and Updated Guidelines Into Managed Care Strategies

Optimizing Lipid Management in Statin-Intolerant Populations: Payer Strategies for Evidence-Based Access and Risk Reduction

ASCP 2025 Satellite Symposia

Effective Strategies to Manage Hyperglycemia When Treating with PI3K and AKT Inhibitors

AMCP Nexus 2025

Multidisciplinary Insights and Strategies for Patients Treated With PI3K and AKT Inhibitors to Prevent Hyperglycemia

Asembia Specialty Pharmacy Day of Education 2025