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Opinion|Videos|January 29, 2025

Best Practices in Switching PBC Therapies

Panelists discuss how clinicians may transition patients to newer agents due to factors such as inadequate biochemical response, tolerability issues (particularly pruritus), or patient preference, while carefully considering the need for washout periods based on each drug's pharmacokinetics and mechanism of action.

Episodes in this series

Video content above is prompted by the following:

  1. What are some reasons why clinicians may consider a transition from obeticholic acid to seladelpar or elafibranor for PBC?
  2. Given the different mechanisms of action of obeticholic acid, seladelpar, and elafibranor, what factors should be considered in determining the need for a washout period between treatments vs direct transition?

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