Probiotics Alleviate IBS Symptoms

Pharmacy Times, Volume 0, 0

The etiology of irritable bowel syndrome(IBS) has not been fully defined, and theeffects of probiotics on this gastrointestinal(GI) motility disorder remain unclear. KajsaKajander, MSc, and colleagues conducteda randomized, double-blind, placebo-controlledtrial to investigate the effects of aprobiotic mixture containing Lactobacillusrhamnosus GG, L rhamnosus LC705, Bifidobacteriumbreve Bb99, and Propionibacteriumfreudenreichii subsp shermanii JSon IBS symptoms.

Patients meeting Rome I or Rome II criteriafor IBS (n = 103) were treated with aprobiotic capsule or a placebo daily for 6months. GI symptoms and bowel habitswere recorded.

At the end of the study, the medianreduction in symptom score (abdominalpain + distension + flatulence + borborygmi)was 42% in the probiotic group, comparedwith 6% in the placebo group (P =.015). For individual symptoms, borborygmiwas milder in the probiotic group (P =.008), but no significant trends wereobserved for other individual symptoms.These results suggested that this probioticmixture is effective in alleviating symptomsassociated with IBS (Alimentary Pharmacologyand Therapeutics, September 2005).