Hospital

The pandemic taught the pharmacy to provide a deeper level of personalized care and communication than in the past.

Julie Bullock, VP, global head of clinical pharmacology and translational medicine at Certara, discusses the FDA’s new guidance Project Optimus, which addresses issues relating to dose optimization in clinical trials assessing oncology drugs.

Daratumumab and hyaluronidase-fihj (Darzalex Faspro, Janssen) was approved in July in combination with pomalidomide and dexamethasone for the treatment of patients with multiple myeloma following their first or subsequent relapse.

New treatments show promise for patients with KRAS G12C–mutated disease.

The FDA recently authorized COVID-19 vaccine booster shots for immunocompromised individuals, who comprise about 3% of the US population.

Analyzing how off-target antibodies may be undermining HIV vaccine prototypes allows for design improvements.

The FDA approved pembrolizumab plus lenvatinib for the first-line treatment of adult patients with advanced RCC.

Patients with microsatellite stable (MSS) colorectal cancer, which represents 95% of all metastatic colorectal cancer cases, are more responsive to checkpoint blockade immunotherapy if the patient’s tumors have not spread to the liver.

The investigators found that antibodies generated by a single dose of the Pfizer-BioNTech vaccine was less effective at neutralizing variants of concern, but the second dose dramatically increased responses to virus variants.

The FDA is expected to recommend that individuals with compromised immune systems receive a booster shot of either the Pfizer or Moderna COVID-19 vaccine.

The CDC now recommends COVID-19 vaccination for all individuals 12 years and older in the United States, including those who are pregnant or breastfeeding.

If approved, pembrolizumab would be the first adjuvant immunotherapy option for this patient population with renal cell carcinoma.

The safety of atezolizumab in the Impower010 trial was consistent with its known safety profile and no new safety signals were identified.

Among those who had hypertension, diabetes, and/or obesity as well as COVID-19, the risk rose to 160%.

The requirement to promote a healthy, productive, and safe work environment is borne by all, not just those with a managerial title.

Current guideline recommendations include various combinations of targeted therapy with immunotherapy.

Study suggests that immediate onset mRNA vaccine reactions may not be caused by classic allergy, or IgE-mediated hypersensitivity.

The Independent Data Monitoring Committee concluded that DESTINY-Breast03 met the primary endpoint of progression-free survival and showed a highly statistically significant and clinically meaningful improvement for patients with human epidermal growth factor receptor 2 (HER2)-positive, unresectable and/or metastatic breast cancer previously treated with trastuzumab and a taxane.

The goal of treating heart failure is to reduce symptoms, improve heart function, and increase ejection fraction.

A panel of key stakeholders in the pharmacy field discuss the nature of environmental conditions as a social determinant of health and the potential impact on patient health outcomes, as well as how to best educate patients and colleagues when approaching the subject in the pharmacy.

A number of prescription medications are indicated for the treatment of this aggressive disease.

Polatuzumab vedotin regimen is the first in 2 decades to show such significant improvements.

The partial immune response observed in these patients can create an environment for immune selection of evolutionary variants, according to the authors of the study.

Ten quiz questions to assess your knowledge on common multiple sclerosis treatments.

Multimorbidity, health-related quality of life, and stigma and discrimination continue to be major issues for people living with HIV, including those who have achieved viral suppression, according to a consensus statement from a multidisciplinary panel of HIV experts published in Nature Communications.

The investigators found that the combination of cemiplimab-rwlc and chemotherapy resulted in a substantial improvement in OS compared to chemotherapy alone for patients with metastatic or locally advanced disease and tumors with either squamous or non-squamous histology and across all programmed death-ligand 1 expression levels.

Asparaginase erwinia chrysanthemi (recombinant)-rywn) (Rylaze) is approved for use as a component of a chemotherapy regimen for the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma

Research presented at the Alzheimer’s Association International Conference (AAIC) 2021 found associations between COVID-19 and persistent cognitive deficits, including the pathology and symptoms of Alzheimer disease.

BCC is the most common form of skin cancer and is typically treated with surgical excision. However, excision can be a costly and burdensome treatment, especially for patients with multiple BCC lesions, according to the study.

Truvada is a medicine people at risk for HIV should take to prevent infection with the virus from various ways, such as sex or injection drug use.