Gillian McGovern, Editor

In a phase 1 trial, the nicotine replacement therapy (NRT) demonstrated a higher mean maximum plasma concentration was achieved faster than with an existing inhaled NRT.

Currently, VLS-1488 is being evaluated in a phase 1/2 trial (NCT05902988) in various advanced tumors, including high-grade serous ovarian cancer (HGSOC).

A recent study found that indoor allergen exposure, including mouse and cockroach allergens, led to an increased risk of respiratory viral infections in children with asthma.

The accelerated course was safe and effective and did not increase complications in patients with breast cancer post-mastectomy undergoing breast reconstruction.

C. diff survivor and Peggy Lillis Foundation Board Member Maryann Webb discusses how her experience with the infection encouraged her to advocate for patients who are struggling to advocate for themselves.

The survey demonstrated that adolescents and young adults (AYAs) who preferred health care professionals (HCPs) as sources of information had sufficient knowledge of contraception options available.

The indication is for adult and pediatric patients aged 2 years and older with advanced or metastatic RET-mutated medullary thyroid cancer (MTC) who require systemic therapy.

The estimated vaccine efficacy was approximately 58%, with only 21 patients in the vaccinated group being diagnosed with mpox.

Study results showed that Black women with breast cancer were more likely to die across all subtypes, with the disparity varying from 17% to 50% depending on subtype.

Dupilumab is the first biologic medicine for patients with chronic obstructive pulmonary disease to be approved in the US.

In adolescents, a comprehensive model using behavioral and MRI data had a prediction accuracy of 0.83, which was higher than single data type models.

The authors found that asthma severity was associated with a higher risk of type 2 diabetes, with the risk increasing in line with severity, but not asthma duration.

The authors note that changes in the adolescent guidelines for meningococcal and human papillomavirus vaccines may cause inconsistencies and nonadherence.

About 72% of the observed pregnancies after allogeneic hematopoietic cell transplantation occurred spontaneously, whereas remaining pregnancies were a result of assisted reproductive activities.

Compared with chemotherapy, datopotamab deruxtecan (Dato-DXd) did not achieve a statistically significant overall survival (OS) in patients with inoperable or metastatic HR+/HER2-low or negative breast cancer.

A 95% increase in private health center participation, monitoring, assessment, and vaccine coverage can be significant in improving outcomes.

Although dry-powder and soft-mist inhalers had significantly lower emissions, they represented nearly two-thirds of inhaler costs but one-third of claims.

The authors note this is the first study to assess cerebrovascular endothelial extracellular vesicles within a cognitive condition.

The researchers estimate that pregnancy losses because of malaria and parasitemia risk before conception was reduced by 65% to 86%.

The chief product and strategy officer at Linus Health is hopeful that pharmacists can be key players in the detection of mild cognitive impairment.

The CRAFT (NCT04551521) trial is still ongoing to assess findings in the remaining patient arms.

Using ultrasound and clinicopathological characteristics, the studied nomograms effectively evaluated recurrence risk in HR-/HER2+ and HR+/HER2+ breast cancer.

Seroconversion was observed in 95.8% of participants but dropped to 75.6% at the 4-year follow-up.

The authors also found that there was a higher frequency of miscarriages compared with women who did not have asthma.

Additionally, the authors are concerned by the lack of increase in depressive or anxiety diagnoses, indicating potential barriers to care.

The authors urge that screening, prevention, and treatment of anxiety and depression should be important health care priorities for youth who have chronic pain.

The investigators of the phase 3b trial (NCT04838444) will continue to follow up with patients for up to 10 years.

To help with treatment response and compliance as well as optimize treatment, communication between patients and health care providers is necessary.

Despite the new human case, which is not known to be related to animal exposure, the CDC emphasizes that risk to the general public remains low.

Presenter Krish Patel, MD, discusses the use of epcoritamab (Epkinly; AbbVie) and glofitamab (Columvi; Genentech) in aggressive B-cell lymphomas as monotherapies and in combination regimens.