Recombinant zoster vaccination against shingles was found to significantly reduce the risk of heart disease and dementia, even after a prior case of shingles.
Recombinant zoster vaccination (RZV) against herpes zoster (shingles) can reduce the risk of heart disease, dementia, and death in patients aged 50 and older, according to research presented at IDWeek 2025 in Atlanta, Georgia.1
Investigators led by Ali Dehghani, DO, doctor of internal medicine at Case Western Reserve University’s School of Medicine, analyzed the health records of over 174,000 adults from dozens of United States health systems. The researchers followed vaccinated participants for 3 months to 7 years post-vaccination, comparing outcomes from the shingles vaccine to the pneumococcal conjugate vaccine (PCV).1
Individuals who received the shingles vaccine had a 25% lower risk of heart attack or stroke, a 27% lower risk of blood clots, a 50% lower risk of vascular dementia, and a 21% lower risk of death. Furthermore, among adults who received RZV, outcomes were directionally favorable versus PCV across prespecified follow-up windows, with hazard ratios generally below 1.0 for the primary outcomes.1,2
“This [data] reinforces the value of shingles vaccination as part of whole-person prevention,” Dehghani said in an interview. “It is still first and foremost a shingles-prevention vaccine, but these data support discussing vaccination in the broader context of heart and brain health while being transparent that these are observational associations.”2
The data were presented as evidence grows linking the varicella-zoster virus to vascular disease. The American Heart Association cites 2022 data from over 200,000 adults, which found that individuals who had a history of shingles had a nearly 20% increased risk of experiencing a future cardiovascular event. This includes up to a 38% higher risk of having a stroke and up to a 25% risk of developing coronary heart disease, encompassing myocardial infarction or needing a heart procedure.1,3
Although Dehghani cautions against framing the data as an indicator that shingles can cause heart attacks or dementia, the results support a more nuanced understanding of the virus and its long-term complications. Dehghani notes that shingles may be a systemic signal of thrombo-ischemic outcomes and vascular cognitive diagnoses; counseling on shingles prevention should center not only on avoiding rash and pain but also on reducing downstream vascular vulnerability.2
An aspect of the study that Dehghani explained in further detail was the use of PCV as an active comparator. Dehghani wanted to ensure that the comparison utilized in the study was more thorough than simply comparing vaccinated versus unvaccinated individuals, as such a comparison could “inflate apparent benefits due to healthy-vaccinee bias and differences in health care engagement.” Including PCV as a comparator ensures both groups “have demonstrated preventive-care behavior and vaccine access,” according to Dehghani.1,2
“In plain language, it helps ensure we are not simply measuring ‘people who get vaccines do better,’” Dehghani explained.2
A key observation was found in a sensitivity analysis, which demonstrated similar directions of protection regardless of whether RZV occurred before or after the shingles episode. Dehghani noted that this argues against the point of view that if you can prevent the first rash, you can prevent other complications. Rather, patients who previously had shingles can still receive protection against both a recurrence of shingles and downstream complications.1,2
Dehghani explained that pharmacists are uniquely positioned to translate population-level data into a patient’s personal health choices. Pharmacists can practically counsel patients by informing them on the highly effective nature of RZV, with extensive post-licensure safety monitoring. By adding a layer about why vaccination matters directly to the patient—discussing the increased risk of cardiovascular events, for example—pharmacists can responsibly encourage individuals to vaccinate.1,2
Additionally, pharmacists are in a pivotal position to normalize the short-term side effects of RZV, potentially combatting the seeds of misinformation before they blossom. Practical planning, like scheduling vaccination around important events and hydration, should be encouraged. Perhaps most importantly—and an aspect that is often overlooked, according to Dehghani—is that RZV can still be beneficial even if a patient previously had shingles.2
In lieu of further research that can feature stronger causal designs and include analyses of dose completion and high-risk subgroups, Dehghani highlights that pharmacists can help support uptake “right now.” They can identify eligible patients for vaccination, implement strong workflows and reminders to ensure completion of the vaccine series, and continue strong pharmacovigilance and safety reporting.2
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