Tourette's Syndrome: A Common but Treatable Condition

Pharmacy TimesMarch 2010 Central Nervous System
Volume 76
Issue 3

Between 1 and 10 of every 100 children have Tourette's syndrome (TS), a neurodevelopmental disorder with characteristic tics. Pharmacologic and behavioral approaches to treatment for TS are discussed.

Dr. Zanni is a psychologist and healthsystems consultant based in Alexandria, Virginia.

Named after the French neurologist who first described this disorder, Georges Gilles de la Tourette, Tourette’s syndrome (TS) is a neurodevelopmental disorder with onset typically occurring between ages 4 and 6.1 Most pharmacists are familiar with its repetitive motor and vocal tics that wax and wane in various cycles, occur in a spectrum of severities, and sometimes change over time.2 Hallmark symptoms of TS are described in Table 1.

Stereotyping inaccurately portrays TS patients screaming obscenities or gesturing sexual activity. Among men and women diagnosed with TS, coprolalia (involuntary expression of socially unacceptable words) occurs at some point in 19% and 15%, respectively, and copropraxia (socially inappropriate gesturing) occurs in 6% and 5% in men and women, respectively.3

Symptoms typically intensify during periods of anger, excitement, or stress, but subside somewhat during periods of fatigue, calm, or focused enjoyable activity.4 Complex tics may appear coordinated and voluntary. And although some patients exercise inhibitory control for seconds to hours, this merely delays the outburst, which may be more extreme when voluntary control ends.5 Some patients experience premonitory urges or tension just prior to the tic that dissipate once the tic occurs. Tics often persist during sleep, supporting their involuntary nature.6

Prevalence and Clinical Course

Between 6% and 20% of children have TS, with boys up to 4 times more likely to have TS than girls.4 TS typically begins with motor tics. Simple vocal tics follow, and then complex tics may start. Symptom severity peaks between ages 8 and 11, with symptom improvement or resolution in 65% to 80% of patients in early adulthood.2,7,8 For most, TS is a lifetime disorder; only 8% to 10% have complete remission in adulthood.8 Early severity is not predictive of adult severity.8

TS is associated with numerous co- morbidities: up to 50% develop an obsessive-compulsive disorder (OCD), and approximately 25% have comorbid attention-deficit/hyperactivity disorder (ADHD).2,9,10 Additionally, mood and anxiety disorders occur in up to 25% of patients, as do sleep disorders (20%- 50%). Although not life-threatening, approximately 33% to 44% engage in self-injurious behaviors (eg, scratching), possibly because of underlying mood disorders.6,8

Comorbid conditions are often more functionally disruptive than TS itself. Most TS patients have normal intelligence, but severe symptoms, especially those from ADHD and OCD, cause learning difficulties in up to 50% of TS children.6 Social adjustment problems, social isolation, and ridicule by others are common, often leading to depression and anxiety.


TS symptoms are easily confused with those of other disorders, including mental retardation, Wilson’s disease, Meige’s syndrome, Huntington’s disease, neuroacanthocytes, Sydenham’s chorea, amphetamine abuse, schizophrenia, autism, and ADHD.11-13 Sudden medication withdrawal (eg, neuroleptics) also can lead to emergent tics. Semivoluntary suppression of tics, along with their premonitory urges that are relieved when the tic occurs, are clinical features differentiating TS from other disorders.9

Table 2 presents diagnostic criteria for TS. Ideally, clinicians should observe tics for TS directly, but some patients are able to suppress tics during examination. Thus, verbal reports or video recordings are accepted. TS is generally diagnosed 2 to 3 years following symptom onset.7


The precise pathophysiology of TS remains unknown. The basal ganglia, particularly the caudate nucleus and the inferior prefrontal cortex, are implicated. 9 Evidence suggests disinhibition in the cortico-striatal-thalamocortical pathways. 8,9 A neurotransmitter imbalance may underlie TS pathology, and dopaminergic, glutamatergic, GABAergic, serotonergic, cholinergic, noradrenergic, and opioid systems may be involved.8 High concordance in identical twins (85%-90%) suggests a genetic component.8,9

Treatment Issues

Symptom management, and ideally suppression, is the goal of treatment. Treatment strategies and pharmacotherapy must occur in tandem with comorbidity-related treatment goals.

Pharmacotherapy is indicated when tics cause significant social or functional impairment.2 The Practice Committee of the Tourette Syndrome Association Medical Advisory Board rated commonly used agents using published empirical studies (see Table 3).13 A 2-tiered treatment approach is recommended: nonneuroleptic agents for mild tics, and typical and atypical agents for more severe symptoms.8,12 TS responds to significantly lower doses than those used for psychiatric disorders. Low doses are initially prescribed with upward tapering to the effective dose.

Among the first tier, the alpha-adrenergic agonists, which are used primarily for hypertension treatment, are effective, particularly clonidine and guanfacine. Clonidine is also effective in reducing ADHD.1 Children’s doses for clonidine are 0.3 mg daily, and for guanfacine 0.5 to 1.5 mg twice daily.4,7,12

The neuroleptics have been the mainstay of TS treatment, with haloperidol and pimozide both demonstrating equal effectiveness, although pimozide is better tolerated.13 Haloperidol is effective in approximately 70% of cases. Among the atypicals, risperidone is frequently used.7 Side effects, particularly risk for tardive dyskinesia (TD), must be carefully considered. Despite olanzapine’s lower TD risk, children generally tolerate it poorly.

Because TS symptoms wax and wane, and antipsychotics require several weeks for maximum impact, practitioners must be careful not to confuse treatment response with natural symptom waning. The majority of patients usually require medication for up to 2 years, and approximately 15% require long-term pharmacotherapy.7 Once tics appear stable and/or suppressed, gradual dose reduction is recommended.

Emerging Treatments

Habit reversal therapy, a promising psychotherapeutic intervention, involves training to recognize premonitory urges and execute an incompatible tic-opposing response. Other emerging treatment options with reported positive findings include nicotine patch, delta-9-tetrahydrocannabinol, deep brain stimulation, and electroconvulsive therapy.1,7 Bimedial frontal leucotomy and anterior cingulotomy have been used in extreme cases.7

Final Thoughts

As with many childhood disorders, the entire family must be involved in treatment. Parents often benefit from training in behavior management and techniques that foster social skills and self-esteem. â– 


1. Bloch MH. Emerging treatments for Tourette's disorder. Curr Psychiatry Rep. 2008;10:323-30.

2. Singer H, Leffler J, Murray C. Tics and Tourette’s syndrome: a clinical review. Available at Accessed March 2009.

3. Freeman RD, Zinner SH, Müller-Vahl KR, et al. Coprophenomena in Tourette syndrome. Dev Med Child Neurol. 2008 Dec 4. (Epub ahead of print)

4. National Institute of Neurological Disorders and Stroke. Tourette Syndrome Fact Sheet. Available at Accessed January 31, 2006.

5. Tourette Syndrome Association. Tourette syndrome: frequently asked questions. Available at Accessed January 31, 2006.

6. Osmon DC, Smerz JM. Neuropsychological evaluation in the diagnosis and treatment of Tourette's syndrome. Behav Modif. 2005;29:746-83.


Rampello L, Alvano A, Battaglia G, et al.

Tic disorders: from pathophysiology to treatment. J Neurol. 2006;253:1-15.

8. Singer HS. Tourette's syndrome: from behaviour to biology. Lancet Neurol. 2005;4:149-59.

9. Hawley J, Gray S. Tourette syndrome. Avaialbe at Accessed March 3, 2009.

10. Burd L, Li Q, Kerbeshian J, Klug MG, Freeman RD. Tourette syndrome and comorbid pervasive developmental disorders. J Child Neurol. 2009;24:170-5.

11. Bruun RD

, Cohen DJ, Leckman JF. Guide to the diagnosis and treatment of Tourette syndrome. Tourette Syndrome Association. Available at Accessed January 31, 2006.

12. Freedman R. Diagnosis and management of Tourette syndrome: practical aspects. Medscape Psychiatry and Mental Health eJournal. 1997;2. Available at Accessed January 31, 2006.

13. Scahill L, Erenberg G, Berlin CM, et al. Tourette Syndrome Association Medical Advisory Board: Practice Committee. Contemporary assessment and pharmacotherapy of Tourette syndrome. NeuroRx. 2006;3:192-206.

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