Pharmacy Clinical Pearl of the Day: Fuchs’ Dystrophy

Fuchs' dystrophy causes fluid build up in the cornea, resulting in swelling.

Clinical Pearl of the Day: Fuchs’ Dystrophy

In Fuchs' dystrophy, fluid builds up in the clear layer (cornea) on the front of the eye, causing it to swell and thicken.


  • Fuchs' dystrophy can lead to glare, blurred or cloudy vision, and eye discomfort.
  • Fuchs' dystrophy usually affects both eyes and can cause vision to gradually worsen over years.
  • Typically, the disease starts when people are in their 30s and 40s, but many patients with Fuchs' dystrophy don't develop symptoms until they reach their 50s or 60s.
  • Symptoms may include blurred or cloudy vision, fluctuation in the vision, glare, seeing halos, pain or grittiness from tiny blisters.
  • Causes: In Fuchs' dystrophy, the endothelial cells gradually die or do not work well, resulting in fluid buildup (edema) within the cornea. This causes corneal thickening and blurred vision.
  • Risk factors include sex, genetics, and age
  • Treatment may include eye medications, including saline drops, soft contact lenses, and surgery involving transplanting the cornea.


Fuchs' dystrophy - Symptoms and causes - Mayo Clinic

fuchs disease - Google Search