Pharmacy Clinical Pearl of the Day: Churg-Strauss Syndrome

Clinical Pearl of the Day: Churg-Strauss Syndrome

Churg-Strauss syndrome is a disorder marked by blood vessel inflammation.

Insight:

• This inflammation can restrict blood flow to organs and tissues, sometimes permanently damaging them.
• This condition is also known as eosinophilic granulomatosis with polyangiitis (EGPA).
• Adult-onset asthma is the most common sign of Churg-Strauss syndrome.
• Symptoms may include loss of appetite, weight loss, joint and muscle pain, abdominal pain, weakness, fatigue, rash, skin sores, pain, numbness and tingling in the hands and feet.
• Complications may include peripheral nerve damage, heart disease, and kidney damage.
• Diagnosis may include blood test, imaging tests, and biopsy of the affected tissue.
• Treatment may include corticosteroids, such as Prednisone, to reduce inflammation; Mepolizumab (Nucala); and other medications such as azathioprine (Azasan, Imuran), benralizumab (Fasenra), cyclophosphamide, methotrexate (Trexall), and rituximab (Rituxan).

Sources:

churg-strauss syndrome - Google Search

Churg-Strauss syndrome - Diagnosis and treatment - Mayo Clinic