Minocycline Topical Foam Now Available for Rosacea in Pharmacies Nationwide


Minocycline is the first product to be approved by the FDA for use in rosacea, a diverse skin condition that most commonly presents with deep facial redness, spider veins, and acne-like inflammatory lesions.

Minocycline (Zilxi, VYNE) topical foam, 1.5%, is now available by prescription for the treatment of inflammatory lesions of rosacea in adults. Minocycline is the first product of any form to be approved by the FDA for use in rosacea, a diverse skin condition that most commonly presents with symptoms such as deep facial redness, spider veins, and acne-like inflammatory lesions.1

The once-daily therapy will be available in retail, community, and specialty pharmacies nationwide.1

“Patients and physicians have been seeking new treatment options for rosacea, a condition that can be difficult to treat, leaving many patients dissatisfied and, in some cases, switching treatments multiple times or discontinuing altogether,” said David Domzalski, chief executive officer of VYNE, in a press release. “By combining a unique topical delivery system for minocycline with strong efficacy and tolerability, ZILXI is positioned to address a very challenging skin condition in a way that could change treatment considerations for rosacea.”1

Minocycline was approved by the FDA on May 29, 2020, for the treatment of inflammatory lesions of rosacea in adults and is considered a tetracycline medicine. Some serious adverse effects of minocycline include loss of appetite, tiredness, sleepiness, fever, and blurred vision.2

For those who suffer with rosacea during the coronavirus disease 2019 pandemic, the National Rosacea Society recommends sticking to your skincare routine and maintaining a semblance of a normal life as much possible.3

Further, protecting the skin as best as possible from the mask can maintain skin barrier function and reduce potential irritation or abrasion, according to a VYNE press release.3

“If you have to go into public, try to always use a new or clean mask,” said Estee Williams, MD, assistant professor of dermatology at Mount Sinai School of Medicine, in a press release. “As N95 masks are only recommended for a specific situation, we are advising that everyone else protect themselves with plain cloth masks. Soft, natural materials like cotton are a great fabric choice for rosacea patients.”3


  • VYNE therapeutics announces ZILXI™ (minocycline) topical foam, 5% available in pharmacies nationwide on October 1st [email]. VYNE Therapeutics. Accessed October 1, 2020.
  • Menlo Therapeutics receives FDA approval of ZILXI™ (minocycline) topical foam, 1.5%, the first topical minocycline treatment for rosacea. Menlo Therapeutics. http://www.menlotherapeutics.com/newsroom/menlo-therapeutics-receives-fda-approval-of-zilxi-minocycline-topical-foam-1-5-the-first-topical-minocycline-treatment-for-rosacea/. Published May 29, 2020. Accessed October 1, 2020.
  • Avoiding rosacea flare-ups during the COVID-19 pandemic. National Rosacea Society. https://www.rosacea.org/blog/2020/april/avoiding-rosacea-flare-ups-during-covid-19-pandemic. Published April 22, 2020. Accessed October 1, 2020.

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