FDA Approves Keytruda for Treatment of Hodgkin Lymphoma

Article

Merck has announced the FDA’s approval of Keytruda’s indication for treatment in classical Hodgkin lymphoma (cHL) patients.

Merck has announced the FDA’s approval of Keytruda’s indication for treatment in classical Hodgkin lymphoma (cHL) patients. Keytruda (pembrolizumab) is approved for use in adult patients at a fixed dose of 200 mg and in pediatric patients at a dose of 2 mg/kg with refractory or relapsed cHL.

This indication is based on tumor response rate and durability of response evaluated in a clinical trial. The trial included 210 patients who demonstrated an overall response rate of 69% with a complete remission rate of 22% and a partial remission rate of 47%.

Pembrolizumab is already approved to treat advanced non-small cell lung cancer, advanced melanoma, and head and neck squamous cell cancer.

“For the patients with classical Hodgkin lymphoma who are not cured with existing treatments, there are limited options, and treating their disease becomes more challenging,” Craig Moskowitz, MD, clinical director, division of hematologic oncology of Memorial Sloan Kettering Cancer Center, said in a press release. “This approval is an important step forward in treating these patients, who are generally young and have a particularly poor prognosis, and gives us opportunity to help patients in their fight against this devastating disease.”

Keytruda is administered intravenously every 3 weeks until disease progression or unacceptable toxicity, or up to 24 months in patients without disease progression.

Reference

FDA Approves Merck’s Keytruda ® (pembrolizumab) for adult and pediatric patients with classical hodgkin lymphoma (cHL) refractory to treatment, or who have relapsed after 3 or more prior lines of therapy [news release]. New Jersey. Merck’s website. http://www.mrknewsroom.com/news-release/corporate-news/fda-approves-mercks-keytruda-pembrolizumab-adult-and-pediatric-patients-. Accessed March 15, 2017.

Related Videos
Atopic dermatitis on a patient's hand -- Image credit: Ольга Тернавская | stock.adobe.com
cropped view of man performing chest compression on dummy during cpr training class - Image credit: LIGHTFIELD STUDIOS | stock.adobe.com
Medicine law concept. Judges gavel with pills | Image Credit: Iren Moroz - stock.adobe.com
Image credit: New Africa | stock.adobe.com
biosimilar word or concept represented by wooden letter tiles on a wooden table with glasses and a book | Image Credit: lexiconimages - stock.adobe.com
Image credit: alicja neumiler | stock.adobe.com
Laboratory test tubes and solution with stethoscope background | Image Credit: Shutter2U - stock.adobe.com
Image Credit: Pixel-Shot | stock.adobe.com
© 2024 MJH Life Sciences

All rights reserved.