Esketamine Nasal Spray Shows Promise Depression Relapse


Esketamine is a glutamate receptor modulator capable of restoring synaptic connections in the brains of patients with depression.

New results from a couple of long-term phase 3 clinical trials report the investigational compound esketamine nasal spray is efficacious and safe in delaying relapse time for patients with treatment-resistant depression.

The research, from Janssen Pharmaceutical Companies of Johnson & Johnson, assessed esketamine nasal spray plus oral antidepressant versus placebo plus oral antidepressant in delaying time to relapse of depression symptoms in patients who suffer from treatment-resistant depression. It follows 2 studies presented at the American Psychiatric Assocation's Annual Meeting in New York, NY, las week, which showed the drug's efficacy in short-term duration.

The findings are significant both for the drug — which is being considered for US Food and Drug Administration (FDA) — and for a worldwide patient population of more than 300 million. The therapy is a glutamate receptor modulator, considered capable of restoring synaptic connections in the brains of patients with depression. Its novel mechanism of action gives it distinction among a limited market of available or effective antidepressant treatments for this patient population. According to Janssen, the common “full antidepressant effect” provides relief after 3-4 weeks.

The first trial, a randomized, double-blind, multi-center study of 705 adult patients directly enrolled or transferred from previous esketamine phase 3 trials, compared 56 or 84 mg nasal spray plus oral antidepressant versus a placebo-antidepressant regimen in intermittent dosing over 16 weeks.

Click to continue reading on MD Magazine.

Related Videos
Woman Physician Talking With Her Patient | Image Credit: LStockStudio -
A health visitor explaining a senior woman how to take pills - Image credit: Halfpoint |
Diabetes patient turn knob on end of insulin pen and dial up correct insulin dose for injection. Scale window on pen syringe showing number of units dose. Medical equipment is easy to self injection - Image credit: Orawan |
© 2023 MJH Life Sciences

All rights reserved.