Daily Medication Pearl: Tosymra (Sumatriptan Nasal Spray) for Migraine

Article

Medication Pearl of the Day: Tosymra (Sumatriptan Nasal Spray)

Indication: Tosymra is indicated for the acute treatment of migraine with or without aura in adults.

Insight:

  • Dosing:The recommended dose of Tosymra is 10 mg given as a single spray in one nostril.
  • Dosage form: Single-dose nasal spray device delivering 10 mg of sumatriptan.
  • Adverse events: Myocardial ischemia, Prinzmetal’s angina, arrhythmias, cerebrovascular events, overuse headache, and seizures.
  • Mechanism of action:Sumatriptan binds with high affinity to human cloned 5-HT1B/1D receptors. Sumatriptan presumably exerts its therapeutic effects in the treatment of migraine headache through agonist effects at the 5-HT1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system, which result in cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release.
  • Manufacturer: Upsher-Smith

Sources:

Related Videos
Pride flags during pride event -- Image credit: ink drop | stock.adobe.com
Female Pharmacist Holding Tablet PC - Image credit: Tyler Olson | stock.adobe.com
African American male pharmacist using digital tablet during inventory in pharmacy - Image credit: sofiko14 | stock.adobe.com
Young woman using smart phone,Social media concept. - Image credit: Urupong | stock.adobe.com
selling mental health medication to man at pharmacy | Image Credit: Syda Productions - stock.adobe.com
Medicine tablets on counting tray with counting spatula at pharmacy | Image Credit: sutlafk - stock.adobe.com
© 2024 MJH Life Sciences

All rights reserved.