Daily Medication Pearl: Semaglutide (Rybelsus) for Diabetes

Semaglutide acts as a GLP-1 receptor agonist that selectively binds to and activates the GLP-1 receptor.

Medication Pearl of the Day: Semaglutide (Rybelsus)

Indication: Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Insight:

  • Dosing: Instruct patients to take semaglutide at least 30 minutes before the first food, beverage, or other oral medications of the day with no more than 4 ounces of plain water only. Waiting less than 30 minutes or taking with food, beverages (other than plain water), or other oral medications will lessen the effect of semaglutide.
  • Dosage form: Tablets of 3 mg, 7 mg, and 14 mg.
  • Adverse events (AEs): The most common AEs, reported in ≥5% of patients treated with semaglutide, are nausea, abdominal pain, diarrhea, decreased appetite, vomiting, and constipation.
  • Drug interactions: With oral medications semaglutide can delay gastric emptying. When co-administering oral medications, instruct patients to closely follow semaglutide administration instructions.
  • Mechanism of Action: Semaglutide is a GLP-1 analogue with 94% sequence homology to human GLP-1. Semaglutide acts as a GLP-1 receptor agonist that selectively binds to and activates the GLP-1 receptor, the target for native GLP-1.
  • Manufacturer: Novo Nordisk

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