Daily Medication Pearl: Pregabalin (Lyrica)

Lyrica is indicated for neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, spinal cord injury nerve pain, and pain after shingles in adult patients.

Medication Pearl of the Day: Pregabalin (Lyrica)

Indication: Lyrica is indicated for neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, spinal cord injury nerve pain, and pain after shingles in adult patients.

Insight:

  • Dosing: For adult indications, begin dosing at 150 mg/day.
  • Dosage forms: Capsules 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, and 300 mg. Oral solution 20 mg/ mL.
  • Adverse events: Most common adverse reactions (greater than or equal to 5% and twice placebo) in adults are dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and thinking abnormal (primarily difficulty with concentration/attention).
  • Mechanism of action: Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues.

Source:

(fda.gov)