Article

Daily Medication Pearl: Lacosamide (Vimpat) Partial-Onset Seizures

Medication Pearl of the Day: Lacosamide (Vimpat)

Lacosamide is indicated for the treatment of partial-onset seizures in patients 1 month of age and older, as well as adjunctive therapy in the treatment of primary generalized tonic-clonic seizures in patients 4 years of age and older.

Insight:

  • Dosing: Initial dosage for monotherapy for the treatment of partial-onset seizures is 100 mg twice daily. Initial dosage for adjunctive therapy for the treatment of partial-onset seizures or primary generalized tonic-clonic seizures is 50 mg twice daily.
  • Dosage forms: 50 mg, 100 mg, 150 mg, 200 mg tablets; 200 mg/20 mL single-dose vial for intravenous use; 10 mg/mL oral solution.
  • Adverse events (AEs): Most common AEs in adults (≥10% and greater than placebo) are diplopia, headache, dizziness, nausea, and somnolence.
  • Mechanism of action: Inhibition of neuronal firing.
  • Manufacturer: ucbCARES

Sources:

Related Videos
Vial of Pneumococcal vaccine - Image credit: Bernard Chantal | stock.adobe.com
Vaccine vials used for Respiratory Syncytial Virus (RSV) with a syringe - Image credit:  Peter Hansen | stock.adobe.com
Older patient with medical health checkup with cardiologist or geriatric doctor. Woman with coronary artery heart disease or cardiac illness check-up in clinic - Image credit: Chinnapong | stock.adobe.com
Pharmacist and patient in a retail/community pharmacy setting -- Image credit: Zamrznuti tonovi | stock.adobe.com