Daily Medication Pearl: Insulin Glargine Injection (Toujeo)


Toujeo is used to improve glycemic control in adults with diabetes mellitus.

Medication Pearl of the Day: Insulin Glargine Injection (Toujeo)

Indication: Toujeo is a long-acting human insulin analog indicated to improve glycemic control in adults with diabetes mellitus.


  • Dosing: Individualize dose based on type of diabetes, metabolic needs, blood glucose monitoring results, and glycemic control.
  • Dosage forms: Injection 300 units/mL insulin glargine in 1.5 mL solostar disposable prefilled pen.
  • Adverse events: Adverse reactions commonly associated with Toujeo (≥5%) are hypoglycemia, allergic reactions, injection site reaction, lipodystrophy, pruritus, rash, edema, and weight gain.
  • Mechanism of action: The primary activity of insulin, including insulin glargine, is regulation of glucose metabolism. Insulin and its analogs lower blood glucose by stimulating peripheral glucose uptake, especially by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis, and enhances protein synthesis.
  • Manufacturer: Sanofi-Aventis


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