Daily Medication Pearl: Insulin Degludec Injection (Tresiba)

Tresiba is indicated to improve glycemic control in patients with diabetes.

Medication Pearl of the Day: Insulin degludec injection (Tresiba)

Indication: Tresiba is a long-acting human insulin analog indicated to improve glycemic control in adults with diabetes mellitus.


  • Dosing: Individualize dose based on type of diabetes, metabolic needs, blood glucose monitoring results, and glycemic control goal.
  • Dosage forms: Tresiba is available in package sizes of 100 units/mL (U-100): 3 mL FlexTouch; 200 units/mL (U-200): 3 mL FlexTouch
  • Adverse events: Hypoglycemia, allergic reactions, injection site reactions, lipodystrophy, 56 pruritus, rash, edema, and weight gain.
  • Mechanism of action: The primary activity of insulin, including Tresiba, is regulation of glucose metabolism.
  • Manufacturer: Tresiba forms multi-hexamers when injected into the subcutaneous (SC) tissue resulting in a SC insulin degludec depot. The protracted time action profile of Tresiba is predominantly due to delayed absorption of insulin degludec from the SC tissue to the systemic circulation and, to a lesser extent, due to binding of insulin-degludec to circulating albumin.



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