Daily Medication Pearl: Ibalizumab-uiyk (Trogarzo)

Medication Pearl of the Day: Ibalizumab-uiyk (Trogarzo)

Indication: Ibalizumab-uiyk (Trogarzo), a CD4-directed post-attachment HIV-1 inhibitor, is indicated for the treatment of HIV-1 infection in combination with other antiretroviral(s), for heavily treatment-experienced adults with multidrug resistant HIV-1 infection who are failing their current antiretroviral regimen.

Insight:

• Dosing: Ibalizumab-uiyk is administered intravenously (IV) as a single loading dose of 2000 mg followed by a maintenance dose of 800 mg every 2 weeks after dilution in 250 mL of 0.9% sodium chloride injection, USP
• Dosage forms: Injection 200 mg/1.33 mL (150 mg/mL) in a single-dose vial.
• Adverse events: The most common adverse reactions (incidence ≥ 5%) were diarrhea, dizziness, nausea, and rash.
• Mechanism of action: Ibalizumab-uiyk is an HIV-1 antiretroviral drug.
• Manufacturer: TaiMed Biologics

Sources:

• TROGARZO™ (ibalizumab-uiyk) injection (fda.gov)
• trogarzo image - Bing images