Daily Medication Pearl: Galcanezumab-gnlm (Emgality)

Medication Pearl of the Day: Galcanezumab-gnlm (Emgality)

Indication: Galcanezumab-gnlm (Emgality) is a calcitonin-gene related peptide (CGRP) antagonist indicated in adults for the preventive treatment of migraine and treatment of episodic cluster headache.


Dosing: Migraine recommended dosage 240 mg loading dose, administered as 2 consecutive injections of 120 mg each, followed by monthly doses of 120 mg.

Dosage forms: Injection 120 mg/mL solution in a single-dose prefilled pen.

Adverse events: The most common adverse reactions (incidence ≥2% and at least 2% greater than placebo) in Emgality clinical studies were injection site reactions.

Mechanism of action: Galcanezumab-gnlm is a humanized monoclonal antibody that binds to the CGRP ligand and blocks its binding to the receptor.

Manufacturer: Eli Lilly