Medication Pearl of the Day: Crestor (Rosuvastatin)
Indication: Crestor is used as an adjunct to diet to reduce elevated total-C, LDL-C, ApoB, non-HDL-C, and TG levels and to increase HDL-C for patients with primary hyperlipidemia and mixed dyslipidemia.
- Dosing time: Crestor can be taken with or without food at any time of day.
- Dose range: Dosing for Crestor can range from 5 to 40 mg once daily. The 40 mg dose should be used only for patients not reaching their LDL-C goal with 20 mg.
- Dosage forms: Tablets for Crestor come in dosage forms of 5 mg, 10 mg, 20 mg, and 40 mg.
- Adverse events (AEs): The most frequent AEs (rate ≥ 2%) are headache, myalgia, abdominal pain, asthenia, and nausea.
- Mechanism of action: Crestor is a selective and competitive inhibitor of HMG-CoA reductase, which is the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, which is a precursor of cholesterol.
- Manufacturer: AstraZeneca
Crestor (rosuvastatin calcium) tablets (fda.gov)