Daily Medication Pearl: Bupropion (Aplenzin)


Bupropion (Aplenzin) is an antidepressant that treats major depressive disorder and seasonal affective disorder.

Medication Pearl of the Day: Bupropion (Aplenzin)

Indication: Bupropion (Aplenzin) is an aminoketone antidepressant, indicated for the treatment of major depressive disorder (MDD) and seasonal affective disorder (SAD). Periodically reevaluate long-term usefulness for the individual patient.


  • Dosing: Starting dose 174 mg once daily (equivalent to 150 mg bupropion HCl). Usual target dose 348 mg once daily (equivalent to 300 mg bupropion HCl).
  • Dosage forms: Extended-release tablets 174 mg, 348 mg, and 522 mg.
  • Adverse events: Most common adverse reactions are (incidence ≥5%; ≥2× placebo rate) dry mouth, nausea, insomnia, dizziness, pharyngitis, abdominal pain, agitation, anxiety, tremor, palpitation, sweating, tinnitus, myalgia, anorexia, urinary frequency, and rash.
  • Mechanism of action: The mechanism of action of bupropion is unknown, as is the case with other antidepressants; however, it is presumed that this action is mediated by noradrenergic and/or dopaminergic mechanisms.
  • Manufacturer: Valeant Pharma


Related Videos
Laboratory test tubes and solution with stethoscope background | Image Credit: Shutter2U - stock.adobe.com
Image credit: Andrea Izzotti
Inflation Reduction Act is shown using the text and the US flag - Image credit: Andrii | stock.adobe.com
Pharmacy Interior | Image Credit: Tyler Olson - stock.adobe.com
Male pharmacist selling medications at drugstore to a senior woman customer | Image Credit: Zamrznuti tonovi - stock.adobe.com
Pharmacist assists senior woman in buying medicine in pharmacy - Image credit: Drazen | stock.adobe.com
Pharmacy, medicine and senior woman consulting pharmacist on prescription. Healthcare, shopping and elderly female in consultation with medical worker for medication box, pills or product in store - Image credit: C Daniels/peopleimages.com | stock.adobe.com
Image credit: fidaolga - stock.adobe.com
Pharmacists checking inventory at hospital pharmacy- Image credit: Jacob Lund | stock.adobe.com
Young male pharmacist giving prescription medications to senior female customer in a pharmacy | Image Credit: Zamrznuti tonovi - stock.adobe.com
© 2023 MJH Life Sciences

All rights reserved.