Daily Medication Pearl: Brimonidine Tartrate/Timolol (Combigan)

Combigan is comprised of 2 components that reduce elevated intraocular pressure, whether or not associated with glaucoma.

Medication Pearl of the Day: Brimonidine tartrate/timolol (Combigan)

Indication: Brimonidine tartrate/timolol (Combigan) is an alpha-adrenergic receptor agonist with a beta-adrenergic receptor inhibitor indicated for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension.

Insight:

  • Dosing: One drop in the affected eye(s), twice daily approximately 12 hours apart.
  • Dosage forms: Solution containing 2 mg/mL brimonidine tartrate and 5 mg/mL timolol.
  • Adverse events: Most common adverse reactions occurring in approximately 5% to 15% of patients include allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperemia, eye pruritus, ocular burning, and stinging
  • Mechanism of action: Combigan is comprised of 2 components: brimonidine tartrate and timolol. Each of these components decreases elevated intraocular pressure, whether or not associated with glaucoma.
  • Manufacturer: Allergan

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