The randomized ALLIANCE A051701 trial closed early when treatment-related toxicity and mortality were increased without improving PFS in patients with newly diagnosed double-hit lymphoma.
|Articles|March 7, 2022
Daily Medication Pearl: Aggrenox (Aspirin/ER, Dipyridamole)
Author(s)Saro Arakelians, PharmD
Aggrenox is indicated to reduce the risk of stroke in patients who have had transient ischemia of the brain or completed ischemic stroke due to thrombosis.
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Medication Pearl of the Day: Aggrenox (Aspirin/ER, Dipyridamole)
Indication: Aggrenox is a combination antiplatelet agent indicated to reduce the risk of stroke in patients who have had transient ischemia of the brain or completed ischemic stroke due to thrombosis.
Insight:
- Dosing: One capsule twice daily (morning and evening) with or without food.
- Dosage forms: Capsule 25 mg aspirin/200 mg extended-release dipyridamole.
- Adverse events (AEs): The most frequently reported AEs (>10% and greater than placebo) were headache, dyspepsia, abdominal pain, nausea, and diarrhea.
- Mechanism of action: The antithrombotic action of Aggrenox is the result of the additive antiplatelet effects of dipyridamole and aspirin.
- Manufacturer: Boehringer Ingelheim
Sources:
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