Acetadote (acetylcysteine) Injection

Pharmacy Times, Volume 0, 0

Cumberland Pharmaceuticals(Nashville,Tenn) recently receivedFDA approval for revisedlabeling for AcetadoteInjection. The product is used in an emergencyroom setting to prevent or lessenpotential liver damage resulting from anoverdose of acetaminophen, a commoningredient in many OTC painkillers.Acetadote, administered intravenouslywithin 8 to 10 hours after ingestion of apotentially hepatotoxic quantity of acetaminophen,is indicated to prevent orlessen hepatic injury. The revised packageinsert includes a dosage guide forpediatric patients who weigh <40 kg. Theloading dose (300 mg/kg) administrationalso has been extended to 60 minutes,making the total recommended treatmenttime 21 hours. Acetadote is availableas a 20% solution in 30-mL (200mg/mL) single-dose vials. For more information,visit www.acetadote.com, or call877-484-2700.