CLINICAL ROLE -
COVID-19 May Be More Deadly for Individuals with Type 2 Diabetes
T2D is associated with a higher mortality risk linked to the coronavirus than individuals with T1D.
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Consider Supportive Therapy, Other Causes When Managing Cytopenia on Tyrosine Kinase Inhibitor Therapy
The recommendation for managing cytopenias among patients treated with tyrosine kinase inhibitors is to discontinue treatment at the onset of grade 3 or higher.
Cetuximab, Encorafenib Combination Granted Expanded Label for Treatment of BRAF V600E Mutation-Positive Metastatic Colorectal Cancer
The combination of cetuximab and encorafenib resulted in a median overall survival of 8.4 months, compared to 5.4 months in the control arm among patients with colorectal cancer.
FDA Approves Oral CGRP Receptor Antagonist Atogepant for Preventive Migraine Treatment
Significant reductions in mean monthly migraine days compared with placebo were seen as early as weeks 1 through 4 in the clinical trial program for atogepant.
The Value of a Hub in a Limited Distribution Specialty Pharmacy Network
Although specialty pharmacies may be able to offer some of the services that a hub provider does, a hub can standardize patient and provider support across the network.
Weight Loss Can Reverse Cardiovascular Risk of Obesity
Study shows that shedding pounds potentially decreases the risk of diabetes, dyslipidemia, and high blood pressure.
Daily Medication Pearl: Amisulpride (Barhemsys) for Postoperative Nausea and Vomiting
Amisulpride is a selective dopamine-2 and -3 receptor antagonist that inhibits postoperative nausea and vomiting.
Pharmacy Clinical Pearl of the Day: Signs and Symptoms of Bipolar Disorder
There are several types of bipolar disorders, including mania or hypomania and depression.
Assessing the Future of CTCL Treatment
Lauren C. Pinter-Brown, MD, FACP, of UCI Health and Chao Family Comprehensive Cancer Center, addresses the areas that may need further investigation to progress advanced cutaneous T cell lymphoma treatments in the future.
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Keytruda Meets Endpoints in KEYNOTE Trial, Treatment of Hepatocellular Carcinoma
The medication has met the criteria of overall survival for individuals with this type of liver cancer who were previously treated with sorafenib, Merck says.
Levetiracetam Improves Cognitive Function for Some Individuals with Alzheimer Disease
Patients with senile dementia who have silent epileptic activity show improvement when taking this medication.
Consider Risk Levels When Treating Polycythemia Vera Before and After Fibrotic Transformation
Risk stratification for survival should not dictate treatment, but stratification for thrombosis risk should play an important role in treatment decisions.
FDA Accepts Cemiplimab-Rwlc for Priority Review for Advanced Cervical Cancer
Cemiplimab-rwlc is being developed by Regeneron and Sanofi under a global collaboration agreement.
Durvalumab, Novel Immunotherapies Improve Clinical Outcomes in Unresectable, Stage III Non-Small Cell Lung Cancer
Durvalumab in combination with oleclumab reduced the risk of non-small cell lung cancer disease progression or death by 56%, whereas patients receiving durvalumab and monalizumab had a 35% reduction.
Pfizer, BioNTech Submit Initial Data to FDA Seeking EUA for COVID-19 Vaccine in Children Ages 5-11
The results were compared to those in the previous Pfizer-BioNTech study in people between 16 and 25 years of age who were immunized with 30 μg doses.
Nivolumab Plus Ipilimumab Shows Promising Overall Survival in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma
The combination maintained superior OS and response benefits versus sunitinib in both patients with intermediate- and poor-risk prognostic factors, the primary endpoint population, and across all randomized patients.
September 2021 Pet Peeves
How would you respond to these situations?
Daily Medication Pearl: Vascepa (Icosapent Ethyl) for Cardiovascular Disease
Vascepa is indicated to reduce the risk of myocardial infarction, stroke, coronary revascularization, and unstable angina requiring hospitalization in adult patients.
Expert: Psychedelic Medicine Allows for Personalized Treatments of Neuropsychiatric Disorders With High Unmet Medical Need
Hans Eriksson, MD, PhD, the chief clinical development officer at HMNC Brain Health, on the development of personalized treatments for neuropsychiatric disorders using precision-medicine.
Older Women and Younger Men Are More Likely to Have Uncontrolled Hypertension
Study results presented at an American Heart Association conference show that 34% of individuals have high blood pressure.
Help Ensure Proper Medication Storage and Disposal
Education is key to providing information about proper techniques and bolstering patient safety.
Pharmacy Clinical Pearl of the Day: Symptoms of Alzheimer Disease
Approximately 5.8 million people in the United States 65 years of age and older live with Alzheimer disease.
Current Research Underway in CTCL Treatment
Lauren C. Pinter-Brown, MD, FACP, of UCI Health and Chao Family Comprehensive Cancer Center, explains what research is underway in the advanced cutaneous T cell lymphoma field that she is currently keeping an eye on.
Targeting MAPK Signaling Pathway May Improve Outcomes for Certain Patients With Leukemia
By deactivating a component of the MAPK signaling pathway, researchers were able to reduce the proportion of leukemia cells in blood and bone marrow.
FDA Approves Evolocumab for Patients Ages 10 and Older With Heterozygous Familial Hypercholesterolemia
Monthly treatment with evolocumab reduced LDL-C by a mean of 38% from baseline compared to placebo among patients ages 10 to 17 with heterozygous familial hypercholesterolemia.
Extended-Release Narcolepsy Drug Shows Promise in Once-a-Night Dose
Investigators at Stanford Medicine find that 72% of individuals who took the highest dose of ON-SXB were considered much or very much improved.
New Generics Are Less Available in Medicare Insurance Plans, Report Shows
Policy makers should consider structural incentives to improve generic drug access, investigators say.
Study Examines Herpes Zoster Reactivation Following COVID-19 Vaccination
A new study examined 3 different cases of chronic urticaria being treated with cyclosporine and patients who developed reactivation of recurrent herpes zoster (HZ) following COVID-19 vaccination.
Expert: There is a Dire Need to Improve, More Effectively Treat Mental Health Disorders for Returning Veterans
Shawn Singh, CEO of VistaGen, discusses how to improve and more effectively treat mental health disorders for returning veterans, who currently account for 20% of all suicides in the United States.
Study: Antibiotic Regimen Can Treat Round Pneumonia in Pediatric Patients
Treatment of round pneumonia should be followed up with a 2-view chest X-ray weeks later.