CLINICAL ROLE -
Jazz Pharmaceuticals Submits Biologics License Application for Zanidatamab to Treat Biliary Tract Cancer
Study outcomes demonstrated that 80 HER2-postive BTC individuals enrolled in Cohort 1 of the study achieved a confirmed objective response rate of 41.3%
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Data Analytics Help Specialty Pharmacies Personalize Health Care
Advanced analytics will continue to make health care more accessible and empower pharmacists with the ability to personalize treatments.
Study Shows Diabetes, Pollution, Alcohol Intake Related to Onset of Cognitive Decline
A study about modifiable risk factors on a “weak spot” in the brain network found that diabetes, pollution, and alcohol were most likely to contribute to dementia disorders.
FDA Accepts BLA for Dato-DXd to Treat Unresectable, Metastatic HR-Positive, HER2-Negative Breast Cancer
The decision follows phase 3 trial results that demonstrated improved progression-free survival and confirmed the safety of Dato-DXd in patients with breast cancer.
As Polypharmacy Grows, Pharmacists Play Essential Role in Medication Education
By implementing easier systems of education for patients, the consequences of polypharmacy could potentially decrease.
Study: Mutation Found to Make Follicular Lymphoma More Susceptible to Experimental Drug
The mutation impacts BAF proteins and can lead to progression of follicular lymphoma, according to the investigators.
Dostarlimab Plus Chemotherapy Demonstrates Significant Overall Survival Benefit in Endometrial Cancer
In the RUBY phase 3 trial, dostarlimab (Jemperli; GSK) with niraparib (Zejula; GSK) had significant progression free survival compared to the standard of care.
Adagrasib Meets Primary Endpoint Among Individuals with KRAS G12C-Mutated Locally Advanced or Metastatic NSCLC
The positive results in both progression-free survival and overall response rate were endorsed in a confirmatory study.
AstraZeneca Caps Inhaled Respiratory Portfolio at $35 For Eligible Patients With Asthma, COPD
The Asthma and Allergy Foundation of America applauded the efforts by AstraZeneca, saying accessibility and affordability can help reduce racial disparities in asthma.
Advise Patients About OTC Options for Treating Motion Sickness
Many cases of motion sickness can be managed safely with available OTC products.
Community Pharmacists Can Help Monitor, Manage Cardiometabolic Parameters in Schizophrenia
Health care professionals providing care to patients using second-generation antipsychotics could benefit from incorporating community pharmacists as members of their team.
FDA Approves Danicopan With C5 Inhibitor Therapy to Treat EVH in Adults With Paroxysmal Nocturnal Hemoglobinuria
Positive phase 3 trial results showed that danicopan was more effective than placebo when treating extravascular hemolysis in paroxysmal nocturnal hemoglobinuria.
Men With Melanoma Who Receive Enhanced Vaccine Experience Improvements in Overall Survival
It is unclear why the vaccines were less effective in women, but researchers note that the findings can be important when determining immune therapy outcomes in patients with melanoma.
Behavioral Interventions Give Hope for Management of Insomnia Beyond the Sleep Specialist’s Office
Stephanie Ashraf, MD, offered clinical experience in managing insomnia at the American Medical Women’s Association (AMWA) 2024 Annual Meeting.
Fecal Microbiota Transplantation Could Be the Answer to the Global Threat of Antimicrobial Resistance
Scientists hypothesize that fecal microbiota transplant restores the recipient’s gut microbiota to an environment that mimics the healthy donor’s microbiota
Study: Anxiety, Depression Treatment Linked With Heart Disease Outcomes
Investigators aimed to determine the impact of psychotherapy or psychopharmacologic treatments on adverse outcomes in individuals with coronary artery disease or heart failure.
Study: Tirzepatide Results in Weight Loss for Individuals With Type 1 Diabetes
Tirzepatide is currently approved for management of type 2 diabetes, improving glucose control, facilitating weight loss, and improving cardiovascular disease outcomes.
Study Results Show Low Prevalence of S. Pneumonia Nasopharynx-Oropharynx Colonization
However, investigators found that the prevalence of Streptococcus pneumoniae nasopharynx-oropharynx colonization was higher among younger adults.
Navigating Paxlovid Interactions With Anticoagulants
Interactions between nirmatrelvir/ritonavir and direct oral anticoagulants is complicated, and a point of contrasting views between the US and EU medical communities.
Experts Establish First Performance Measures of Lifestyle Medicine Treatments
Investigators identify 32 performance measures in the final set grouped into 10 categories of disease or health condition.
Direct Oral Anticoagulant Use for Left Ventricular Thrombus Treatment
An overview of the use of direct oral anticoagulants as an alternative to warfarin in the treatment of left ventricular thrombus.
Utidelone Injectable Granted FDA Orphan Drug Designation for Breast Cancer Brain Metastasis
The recent ODD for the utidelone injectable could offer another treatment option for patients with BCBM.
Researchers Identify Two Mutations Potentially Linked to Rare Blood Disorder
The mutations, C594Y and P735R, were found in the GNE gene and may influence sialylation, a process that is crucial for brain development.
Exposure to Residential Greenness During Pregnancy Associated With Increased Risk of Asthma
The effects were strongest during the spring season and in the third trimester of pregnancy.
Study Finds ALL Genetic Variant That Indicates Why Hispanic, Pediatric Patients Are Likely to Develop Disease
Pediatric patients with the variant were approximately 1.44 times more likely develop ALL compared with children who do not have the variant.
Study: mRNA Technology Holds Potential for Delivery of Tau-Targeting Antibodies
Investigators found that mRNA technology for the delivery of antibody therapeutics were used to target tau in Alzheimer disease and can be applied to other tau targets.
FDA Grants ODD to AP303 for Treatment of Patients With Autosomal Dominant Polycystic Kidney Disease
The ODD comes after AP303 presented meaningful improvements in renal survival in an ADPKD and the completion of the first study that evaluated healthy human participants.
Pharmacy Focus: OTC Contraception and Reproductive Health
Cristin Hackel discusses the current state of OTC contraception options, the differences between OTC and prescription methods, and how pharmacists can promote education and awareness.
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Understanding DSCSA: Insights for All Dispensers
As the full act will be enforced in November 2024, all medication dispensers must ensure they’re fully prepared.
Dramatic Tumor Regression Was Displayed in New Approach to CAR T Therapy
The results displayed a dramatic reduction in the individuals’ tumors within days after single treatment.
