6 Strange Drug Side Effects

OCTOBER 04, 2015
Allison Gilchrist, Associate Editor
Side effects may vary, and occasionally take an odd turn.
Everyone knows the common side effects listed on the label of virtually every prescription drug: nausea, constipation, drowsiness, dry mouth, or allergic reactions.
But sometimes, bizarre side effects can present in certain patients.
Here are some of the more peculiar prescription drug side effects that pharmacists may want to mention to patients:
Urine Color Changes
Many drugs can cause changes in urine color, but certain hues are more alarming than others.
Pharmacists are already aware that phenazopyridine (Pyridium), a common OTC analgesic for urinary tract infections, can turn urine orange or even red. But did you know that other drugs can turn urine blue?
Dyrenium, a CYP1A2 substrate used to treat fluid retention and high blood pressure, sometimes turns urine blue. Other medications with this peculiar side effect include amitriptyline (Elavil), indomethacin (Indocin), and propofol (Diprivan).
Then there are the drugs that can turn urine dark brown or even black, including antimalarial drugs chloroquine and primaquine, and the antibiotic metronidazole (Flagyl).
Although they are interesting, these abnormal urine colors could also signal that something is wrong with the body, such as dehydration or internal bleeding.