Myelofibrosis

Gecacitinib is a novel inhibitor targeting both JAK and ACVR1.

Firas El Chaer, MD, discusses newly-presented data at ASH demonstrating nuvisertib's effectiveness in myelofibrosis.

Measuring end points such as molecular response, cytokines, and histomorphometry may show a greater range of benefits.

Improvements were observed regardless of whether patients initiated ruxolitinib in the second or third line of treatment.

Navtemadlin has demonstrated meaningful efficacy and safety as a monotherapy or combination treatment in various preclinical and clinical trials.

Pelabresib is an investigational, oral, small molecule that inhibits bromodomain and extraterminal (BET) proteins.

The data support the use of supportive anemia care agents in combination with ruxolitinib (Jakafi; Incyte Corp).

Anemia is a very common adverse effect associated with the use of ruxolitinib.

Anemia is a common adverse effect of ruxolitinib, calling for new approaches to mitigate risks.

The addition of navitoclax was associated with durable response and potential disease modification.

Rusfertide may sustain hematocrit levels in patients with polycythemia vera.

According to the study, 20% of patients with myeloproliferative neoplasms progress to blast phase.

The nomogram model demonstrated good predictive capabilities to assess progression risk to overt primary myelofibrosis.

Approximately 15% of patients with polycythemia vera will progress to myelofibrosis.

The study was conducted on a small subgroup of Japanese patients with myelofibrosis.

Treosulfan showed superior benefits to busulfan as a conditioning regimen before allogenic hematopoietic stem cell transplantation (allo-HSCT).

Pelabresib, a BET inhibitor, demonstrated meaningful reductions in spleen inflammation and anemia.

Fedratinib is an orally available, small molecule inhibitor of JAK-2 approved for treatment of myelofibrosis.

The findings may offer patients treatment options beyond symptom palliation.

INCA033989 is a monoclonal antibody that selectively targets mutant calreticulin oncogenic function.

Researchers found that PF4/Cxcl4, a key driver of fibrosis, was up regulated on all proteomes.

Luspatercept reduced the need for transfusion in patients with myelofibrosis (MF).

Disease-related factors include several prognostic scoring systems, such as DIPSS, whereas patient-related factors involve age, comorbidities, spleen size, and anemia.

Pharmacists discuss emerging therapies, challenges, and pharmacists’ vital role in myelofibrosis patient care, emphasizing disease-modifying agents and care team collaboration.